High-resolution Cryo-EM Structure Determination of a-Synuclein—A Prototypical Amyloid Fibril

High-resolution Cryo-EM Structure Determination of a-Synuclein—A Prototypical Amyloid Fibril

The physiological role of a-synuclein (a-syn), an intrinsically disordered presynaptic neuronal protein, is believed to impact the release of neurotransmitters through interactions with the SNARE complex. However, under certain cellular conditions that are not well understood, a-syn will self-assemb...

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Bibliographic Details
Main Authors: Juan Sanchez, Joshua Pierson, Collin Borcik, Chad Rienstra, Elizabeth Wright
Format: Article
Language:English
Published: Bio-protocol LLC 2025-02-01
Series:Bio-Protocol
Online Access:https://bio-protocol.org/en/bpdetail?id=5171&type=0
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