Alpha-Fetoprotein and Novel Tumor Biomarkers as Predictors of Hepatocellular Carcinoma Recurrence after Surgery: A Brilliant Star Raises Again
Alpha-fetoprotein (AFP), des-γ-carboxy prothrombin (DCP), and lens culinaris agglutinin-reactive fraction of AFP (AFP-L3) have been developed with the intent to detect hepatocellular carcinoma (HCC) and for the surveillance of at-risk patients. However, at present, none of these tests can be recomme...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2012/893103 |
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| author | Quirino Lai Fabio Melandro Rafael S. Pinheiro Andrea Donfrancesco Bashir A. Fadel Giovanni B. Levi Sandri Massimo Rossi Pasquale B. Berloco Fabrizio M. Frattaroli |
| author_facet | Quirino Lai Fabio Melandro Rafael S. Pinheiro Andrea Donfrancesco Bashir A. Fadel Giovanni B. Levi Sandri Massimo Rossi Pasquale B. Berloco Fabrizio M. Frattaroli |
| author_sort | Quirino Lai |
| collection | DOAJ |
| description | Alpha-fetoprotein (AFP), des-γ-carboxy prothrombin (DCP), and lens culinaris agglutinin-reactive fraction of AFP (AFP-L3) have been developed with the intent to detect hepatocellular carcinoma (HCC) and for the surveillance of at-risk patients. However, at present, none of these tests can be recommended to survey cirrhotic patients at risk for HCC development because of their suboptimal ability for routine clinical practice in HCC diagnosis. Starting from these considerations, these markers have been therefore routinely and successfully used as predictors of survival and HCC recurrence in patients treated with curative intent. All these markers have been largely used as predictors in patients treated with hepatic resection or locoregional therapies, mainly in Eastern countries. In recent studies, AFP has been proposed as predictor of recurrence after liver transplantation and as selector of patients in the waiting list. Use of AFP modification during the waiting list for LT is still under investigation, potentially representing a very interesting tool for patient selection. The development of a new predictive model combining radiological and biological features based on biological markers is strongly required. New genetic markers are continuously discovered, but they are not already fully available in the clinical practice. |
| format | Article |
| id | doaj-art-8f611bd33b414987b0e41aeb6f3834e0 |
| institution | Kabale University |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-8f611bd33b414987b0e41aeb6f3834e02025-02-03T06:11:53ZengWileyInternational Journal of Hepatology2090-34482090-34562012-01-01201210.1155/2012/893103893103Alpha-Fetoprotein and Novel Tumor Biomarkers as Predictors of Hepatocellular Carcinoma Recurrence after Surgery: A Brilliant Star Raises AgainQuirino Lai0Fabio Melandro1Rafael S. Pinheiro2Andrea Donfrancesco3Bashir A. Fadel4Giovanni B. Levi Sandri5Massimo Rossi6Pasquale B. Berloco7Fabrizio M. Frattaroli8Department of General Surgery and Organ Transplantation, Sapienza University of Rome, Umberto I Policlinic of Rome, Viale del Policlinico 155 00161, Rome, ItalyDepartment of General Surgery and Organ Transplantation, Sapienza University of Rome, Umberto I Policlinic of Rome, Viale del Policlinico 155 00161, Rome, ItalyDepartment of Liver Transplantation, University of São Paulo, Av Dr Eneas de Carvalho Aguiar 255, 05403-010 São Paulo, BrazilDepartment of Surgery, Arzignano, Hospital, ULSS5 Ovest Vicentino, Via Kennedy 2 36071, Arzignano, ItalyGeneral Surgery Department, Assiut University Hospital, Assiut 71515, EgyptDepartment of General Surgery and Organ Transplantation, Sapienza University of Rome, Umberto I Policlinic of Rome, Viale del Policlinico 155 00161, Rome, ItalyDepartment of General Surgery and Organ Transplantation, Sapienza University of Rome, Umberto I Policlinic of Rome, Viale del Policlinico 155 00161, Rome, ItalyDepartment of General Surgery and Organ Transplantation, Sapienza University of Rome, Umberto I Policlinic of Rome, Viale del Policlinico 155 00161, Rome, ItalyDepartment of General Surgery and Organ Transplantation, Sapienza University of Rome, Umberto I Policlinic of Rome, Viale del Policlinico 155 00161, Rome, ItalyAlpha-fetoprotein (AFP), des-γ-carboxy prothrombin (DCP), and lens culinaris agglutinin-reactive fraction of AFP (AFP-L3) have been developed with the intent to detect hepatocellular carcinoma (HCC) and for the surveillance of at-risk patients. However, at present, none of these tests can be recommended to survey cirrhotic patients at risk for HCC development because of their suboptimal ability for routine clinical practice in HCC diagnosis. Starting from these considerations, these markers have been therefore routinely and successfully used as predictors of survival and HCC recurrence in patients treated with curative intent. All these markers have been largely used as predictors in patients treated with hepatic resection or locoregional therapies, mainly in Eastern countries. In recent studies, AFP has been proposed as predictor of recurrence after liver transplantation and as selector of patients in the waiting list. Use of AFP modification during the waiting list for LT is still under investigation, potentially representing a very interesting tool for patient selection. The development of a new predictive model combining radiological and biological features based on biological markers is strongly required. New genetic markers are continuously discovered, but they are not already fully available in the clinical practice.http://dx.doi.org/10.1155/2012/893103 |
| spellingShingle | Quirino Lai Fabio Melandro Rafael S. Pinheiro Andrea Donfrancesco Bashir A. Fadel Giovanni B. Levi Sandri Massimo Rossi Pasquale B. Berloco Fabrizio M. Frattaroli Alpha-Fetoprotein and Novel Tumor Biomarkers as Predictors of Hepatocellular Carcinoma Recurrence after Surgery: A Brilliant Star Raises Again International Journal of Hepatology |
| title | Alpha-Fetoprotein and Novel Tumor Biomarkers as Predictors of Hepatocellular Carcinoma Recurrence after Surgery: A Brilliant Star Raises Again |
| title_full | Alpha-Fetoprotein and Novel Tumor Biomarkers as Predictors of Hepatocellular Carcinoma Recurrence after Surgery: A Brilliant Star Raises Again |
| title_fullStr | Alpha-Fetoprotein and Novel Tumor Biomarkers as Predictors of Hepatocellular Carcinoma Recurrence after Surgery: A Brilliant Star Raises Again |
| title_full_unstemmed | Alpha-Fetoprotein and Novel Tumor Biomarkers as Predictors of Hepatocellular Carcinoma Recurrence after Surgery: A Brilliant Star Raises Again |
| title_short | Alpha-Fetoprotein and Novel Tumor Biomarkers as Predictors of Hepatocellular Carcinoma Recurrence after Surgery: A Brilliant Star Raises Again |
| title_sort | alpha fetoprotein and novel tumor biomarkers as predictors of hepatocellular carcinoma recurrence after surgery a brilliant star raises again |
| url | http://dx.doi.org/10.1155/2012/893103 |
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