The amplitude of low frequency fluctuation and spontaneous brain activity alterations in age-related macular degeneration
BackgroundWet age-related macular degeneration (wAMD) is a vision-threatening eye disease worldwide. The amplitude of low-frequency fluctuation (ALFF) method was used to observe changes in spontaneous brain activity, which may help to investigate the underlying pathological mechanism of AMD.MethodsE...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1507971/full |
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| author | Yan Yan Zhang Jin Yu Hu Qian Ling San Hua Xu Min Kang Hong Wei Jie Zou Quanyong Yi Gang Tan Yi Shao Yi Shao |
| author_facet | Yan Yan Zhang Jin Yu Hu Qian Ling San Hua Xu Min Kang Hong Wei Jie Zou Quanyong Yi Gang Tan Yi Shao Yi Shao |
| author_sort | Yan Yan Zhang |
| collection | DOAJ |
| description | BackgroundWet age-related macular degeneration (wAMD) is a vision-threatening eye disease worldwide. The amplitude of low-frequency fluctuation (ALFF) method was used to observe changes in spontaneous brain activity, which may help to investigate the underlying pathological mechanism of AMD.MethodsEighteen patients with wAMD and 18 age- and gender-matched healthy controls (HCs) were recruited. The ALFF method was used on each subject and mean ALFF values were compared between groups. The receiver operating characteristic (ROC) curve was used to compare the two groups.ResultsALFF values in the temporal lobe and limbic lobe/parahippocampal gyrus were significantly higher than controls, while values in the postcentral gyrus were significantly lower. The under the curve of the ROC (AUC) of the three regions shows high accuracy of the diagnosis.ConclusionThe abnormal spontaneous brain activity of patients with AMD suggests scope for the use of ALFF in the diagnosis or prognosis in AMD. |
| format | Article |
| id | doaj-art-8f573ab104b740f6b7e17ef5a638439f |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-8f573ab104b740f6b7e17ef5a638439f2025-01-22T07:11:25ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011110.3389/fmed.2024.15079711507971The amplitude of low frequency fluctuation and spontaneous brain activity alterations in age-related macular degenerationYan Yan Zhang0Jin Yu Hu1Qian Ling2San Hua Xu3Min Kang4Hong Wei5Jie Zou6Quanyong Yi7Gang Tan8Yi Shao9Yi Shao10Ningbo Eye Hospital, Wenzhou Medical University, Ningbo, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Centre of National Clinical Research Ophthalmology Center, Nanchang, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Centre of National Clinical Research Ophthalmology Center, Nanchang, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Centre of National Clinical Research Ophthalmology Center, Nanchang, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Centre of National Clinical Research Ophthalmology Center, Nanchang, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Centre of National Clinical Research Ophthalmology Center, Nanchang, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Centre of National Clinical Research Ophthalmology Center, Nanchang, ChinaNingbo Eye Hospital, Wenzhou Medical University, Ningbo, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of University of South China, Hunan Center of National Ocular Disease Clinical Research Center, Hengyan, ChinaNingbo Eye Hospital, Wenzhou Medical University, Ningbo, ChinaDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai, ChinaBackgroundWet age-related macular degeneration (wAMD) is a vision-threatening eye disease worldwide. The amplitude of low-frequency fluctuation (ALFF) method was used to observe changes in spontaneous brain activity, which may help to investigate the underlying pathological mechanism of AMD.MethodsEighteen patients with wAMD and 18 age- and gender-matched healthy controls (HCs) were recruited. The ALFF method was used on each subject and mean ALFF values were compared between groups. The receiver operating characteristic (ROC) curve was used to compare the two groups.ResultsALFF values in the temporal lobe and limbic lobe/parahippocampal gyrus were significantly higher than controls, while values in the postcentral gyrus were significantly lower. The under the curve of the ROC (AUC) of the three regions shows high accuracy of the diagnosis.ConclusionThe abnormal spontaneous brain activity of patients with AMD suggests scope for the use of ALFF in the diagnosis or prognosis in AMD.https://www.frontiersin.org/articles/10.3389/fmed.2024.1507971/fullthe amplitude of low-frequency fluctuationage-related macular degenerationspontaneous brain activityfunctional magnetic resonance imagingresting brain activity |
| spellingShingle | Yan Yan Zhang Jin Yu Hu Qian Ling San Hua Xu Min Kang Hong Wei Jie Zou Quanyong Yi Gang Tan Yi Shao Yi Shao The amplitude of low frequency fluctuation and spontaneous brain activity alterations in age-related macular degeneration Frontiers in Medicine the amplitude of low-frequency fluctuation age-related macular degeneration spontaneous brain activity functional magnetic resonance imaging resting brain activity |
| title | The amplitude of low frequency fluctuation and spontaneous brain activity alterations in age-related macular degeneration |
| title_full | The amplitude of low frequency fluctuation and spontaneous brain activity alterations in age-related macular degeneration |
| title_fullStr | The amplitude of low frequency fluctuation and spontaneous brain activity alterations in age-related macular degeneration |
| title_full_unstemmed | The amplitude of low frequency fluctuation and spontaneous brain activity alterations in age-related macular degeneration |
| title_short | The amplitude of low frequency fluctuation and spontaneous brain activity alterations in age-related macular degeneration |
| title_sort | amplitude of low frequency fluctuation and spontaneous brain activity alterations in age related macular degeneration |
| topic | the amplitude of low-frequency fluctuation age-related macular degeneration spontaneous brain activity functional magnetic resonance imaging resting brain activity |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1507971/full |
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