Association between blood urea nitrogen to creatinine ratio and 3-month outcome in patients with acute ischaemic stroke: a retrospective cohort study from a large healthcare system
Objectives The blood urea nitrogen to creatinine (BUN/Cr) ratio is associated with early neurological deterioration in acute ischaemic stroke (AIS). However, the predictive value of the BUN/Cr ratio for the AIS prognosis remains unclear. Therefore, we evaluated the correlation between the BUN/Cr rat...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2024-07-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/14/7/e085912.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850087482186530816 |
|---|---|
| author | Hui Li Mingquan Li Lina Wang Ling Liu Yanli Zhang Liumin Wang Xinmei Zhu Boluo Jia Wen Xie |
| author_facet | Hui Li Mingquan Li Lina Wang Ling Liu Yanli Zhang Liumin Wang Xinmei Zhu Boluo Jia Wen Xie |
| author_sort | Hui Li |
| collection | DOAJ |
| description | Objectives The blood urea nitrogen to creatinine (BUN/Cr) ratio is associated with early neurological deterioration in acute ischaemic stroke (AIS). However, the predictive value of the BUN/Cr ratio for the AIS prognosis remains unclear. Therefore, we evaluated the correlation between the BUN/Cr ratio and the 3-month outcome in patients with AIS, further testing their dose–response relationship.Design This retrospective cohort study enrolled patients with AIS who were admitted between 1 January 2013 and 31 May 2022. Poor clinical outcome was defined as 3-month Modified Rankin Scale (mRS) >2. Cox proportional HR was used to evaluate the correlation between the BUN/Cr ratio and 3-month outcome. Restricted cubic spline and robust locally weighted regression analyses were conducted to determine the dose–response relationship between the BUN/Cr ratio and the 3-month outcome.Results A total of 4952 eligible patients were included in the study. The patients were divided into three groups according to the tertiles of BUN/Cr ratio (T1, <0.071; T2, 0.071–0.093; and T3, >0.093). After logistic regression adjustment for demographic and clinical characteristics, the BUN/Cr ratio was found to be independently associated with the 3-month outcome in patients with AIS. The restricted cubic spline and locally regression smoothing scatterplot graph showed a strong dose–response relationship between the BUN/Cr ratio and the 3-month outcome in patients with AIS.Conclusion A dose–response relationship was observed between the BUN/Cr ratio and the 3-month outcome in patients with AIS, suggesting that the BUN/Cr ratio could serve as a reliable predictor for the AIS prognosis. |
| format | Article |
| id | doaj-art-8f50e09d29fe40a8b215b7e3b3fe98c0 |
| institution | DOAJ |
| issn | 2044-6055 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-8f50e09d29fe40a8b215b7e3b3fe98c02025-08-20T02:43:12ZengBMJ Publishing GroupBMJ Open2044-60552024-07-0114710.1136/bmjopen-2024-085912Association between blood urea nitrogen to creatinine ratio and 3-month outcome in patients with acute ischaemic stroke: a retrospective cohort study from a large healthcare systemHui Li0Mingquan Li1Lina Wang2Ling Liu3Yanli Zhang4Liumin Wang5Xinmei Zhu6Boluo Jia7Wen Xie82Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USADepartment of Neurology, Taikang Xianlin Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, ChinaSchool of Medicine, Huzhou University, Huzhou Central Hospital, Huzhou, Zhejiang, ChinaChongqing Medical University, Chongqing, ChinaDepartment of Neurology, Taikang Xianlin Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, ChinaDepartment of Neurology, Taikang Xianlin Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, ChinaDepartment of Neurology, Taikang Xianlin Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, ChinaNanjing Qixia District Xigang Community Health Service Center, Nanjing, China3 Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaObjectives The blood urea nitrogen to creatinine (BUN/Cr) ratio is associated with early neurological deterioration in acute ischaemic stroke (AIS). However, the predictive value of the BUN/Cr ratio for the AIS prognosis remains unclear. Therefore, we evaluated the correlation between the BUN/Cr ratio and the 3-month outcome in patients with AIS, further testing their dose–response relationship.Design This retrospective cohort study enrolled patients with AIS who were admitted between 1 January 2013 and 31 May 2022. Poor clinical outcome was defined as 3-month Modified Rankin Scale (mRS) >2. Cox proportional HR was used to evaluate the correlation between the BUN/Cr ratio and 3-month outcome. Restricted cubic spline and robust locally weighted regression analyses were conducted to determine the dose–response relationship between the BUN/Cr ratio and the 3-month outcome.Results A total of 4952 eligible patients were included in the study. The patients were divided into three groups according to the tertiles of BUN/Cr ratio (T1, <0.071; T2, 0.071–0.093; and T3, >0.093). After logistic regression adjustment for demographic and clinical characteristics, the BUN/Cr ratio was found to be independently associated with the 3-month outcome in patients with AIS. The restricted cubic spline and locally regression smoothing scatterplot graph showed a strong dose–response relationship between the BUN/Cr ratio and the 3-month outcome in patients with AIS.Conclusion A dose–response relationship was observed between the BUN/Cr ratio and the 3-month outcome in patients with AIS, suggesting that the BUN/Cr ratio could serve as a reliable predictor for the AIS prognosis.https://bmjopen.bmj.com/content/14/7/e085912.full |
| spellingShingle | Hui Li Mingquan Li Lina Wang Ling Liu Yanli Zhang Liumin Wang Xinmei Zhu Boluo Jia Wen Xie Association between blood urea nitrogen to creatinine ratio and 3-month outcome in patients with acute ischaemic stroke: a retrospective cohort study from a large healthcare system BMJ Open |
| title | Association between blood urea nitrogen to creatinine ratio and 3-month outcome in patients with acute ischaemic stroke: a retrospective cohort study from a large healthcare system |
| title_full | Association between blood urea nitrogen to creatinine ratio and 3-month outcome in patients with acute ischaemic stroke: a retrospective cohort study from a large healthcare system |
| title_fullStr | Association between blood urea nitrogen to creatinine ratio and 3-month outcome in patients with acute ischaemic stroke: a retrospective cohort study from a large healthcare system |
| title_full_unstemmed | Association between blood urea nitrogen to creatinine ratio and 3-month outcome in patients with acute ischaemic stroke: a retrospective cohort study from a large healthcare system |
| title_short | Association between blood urea nitrogen to creatinine ratio and 3-month outcome in patients with acute ischaemic stroke: a retrospective cohort study from a large healthcare system |
| title_sort | association between blood urea nitrogen to creatinine ratio and 3 month outcome in patients with acute ischaemic stroke a retrospective cohort study from a large healthcare system |
| url | https://bmjopen.bmj.com/content/14/7/e085912.full |
| work_keys_str_mv | AT huili associationbetweenbloodureanitrogentocreatinineratioand3monthoutcomeinpatientswithacuteischaemicstrokearetrospectivecohortstudyfromalargehealthcaresystem AT mingquanli associationbetweenbloodureanitrogentocreatinineratioand3monthoutcomeinpatientswithacuteischaemicstrokearetrospectivecohortstudyfromalargehealthcaresystem AT linawang associationbetweenbloodureanitrogentocreatinineratioand3monthoutcomeinpatientswithacuteischaemicstrokearetrospectivecohortstudyfromalargehealthcaresystem AT lingliu associationbetweenbloodureanitrogentocreatinineratioand3monthoutcomeinpatientswithacuteischaemicstrokearetrospectivecohortstudyfromalargehealthcaresystem AT yanlizhang associationbetweenbloodureanitrogentocreatinineratioand3monthoutcomeinpatientswithacuteischaemicstrokearetrospectivecohortstudyfromalargehealthcaresystem AT liuminwang associationbetweenbloodureanitrogentocreatinineratioand3monthoutcomeinpatientswithacuteischaemicstrokearetrospectivecohortstudyfromalargehealthcaresystem AT xinmeizhu associationbetweenbloodureanitrogentocreatinineratioand3monthoutcomeinpatientswithacuteischaemicstrokearetrospectivecohortstudyfromalargehealthcaresystem AT boluojia associationbetweenbloodureanitrogentocreatinineratioand3monthoutcomeinpatientswithacuteischaemicstrokearetrospectivecohortstudyfromalargehealthcaresystem AT wenxie associationbetweenbloodureanitrogentocreatinineratioand3monthoutcomeinpatientswithacuteischaemicstrokearetrospectivecohortstudyfromalargehealthcaresystem |