Physicochemical characterization and dissolution studies of acyclovir solid dispersions with Pluronic F127 prepared by the kneading method
The dissolution rate of anhydrous acyclovir was improved by the preparation of physical mixtures and solid dispersions with the non-ionic polymer Pluronic F127 using the kneading method at different drug-to-polymer ratios. The obtained physical mixtures and solid dispersions were examined in terms o...
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| Format: | Article |
| Language: | English |
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Sciendo
2016-03-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.1515/acph-2016-0008 |
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| author | Karolewicz Bożena Nartowski Karol Pluta Janusz Górniak Agata |
| author_facet | Karolewicz Bożena Nartowski Karol Pluta Janusz Górniak Agata |
| author_sort | Karolewicz Bożena |
| collection | DOAJ |
| description | The dissolution rate of anhydrous acyclovir was improved by the preparation of physical mixtures and solid dispersions with the non-ionic polymer Pluronic F127 using the kneading method at different drug-to-polymer ratios. The obtained physical mixtures and solid dispersions were examined in terms of drug content and possible physical and chemical interactions between the drug and polymer using FTIR spectral studies, differential scanning calorimetry and powder X-ray diffraction analysis. The dissolution rate of acyclovir was determined using the rotating disk method. It was found that the minimal content of the polymer within the mixtures needed to increase the dissolution rate of the drug was 50 %. |
| format | Article |
| id | doaj-art-8f4f50f926914ff59d2d4fbde03f4e6a |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2016-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-8f4f50f926914ff59d2d4fbde03f4e6a2025-02-02T09:57:48ZengSciendoActa Pharmaceutica1846-95582016-03-0166111912810.1515/acph-2016-0008acph-2016-0008Physicochemical characterization and dissolution studies of acyclovir solid dispersions with Pluronic F127 prepared by the kneading methodKarolewicz Bożena0Nartowski Karol1Pluta Janusz2Górniak Agata3 Department of Drug Form Technology, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw 50556, Poland Department of Drug Form Technology, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw 50556, Poland Department of Drug Form Technology, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw 50556, Poland Laboratory of Elemental Analysis and Structural Research, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw 50556, PolandThe dissolution rate of anhydrous acyclovir was improved by the preparation of physical mixtures and solid dispersions with the non-ionic polymer Pluronic F127 using the kneading method at different drug-to-polymer ratios. The obtained physical mixtures and solid dispersions were examined in terms of drug content and possible physical and chemical interactions between the drug and polymer using FTIR spectral studies, differential scanning calorimetry and powder X-ray diffraction analysis. The dissolution rate of acyclovir was determined using the rotating disk method. It was found that the minimal content of the polymer within the mixtures needed to increase the dissolution rate of the drug was 50 %.https://doi.org/10.1515/acph-2016-0008acyclovirpluronic f127solid dispersionsphysical mixtureskneadingdissolution improvement |
| spellingShingle | Karolewicz Bożena Nartowski Karol Pluta Janusz Górniak Agata Physicochemical characterization and dissolution studies of acyclovir solid dispersions with Pluronic F127 prepared by the kneading method Acta Pharmaceutica acyclovir pluronic f127 solid dispersions physical mixtures kneading dissolution improvement |
| title | Physicochemical characterization and dissolution studies of acyclovir solid dispersions with Pluronic F127 prepared by the kneading method |
| title_full | Physicochemical characterization and dissolution studies of acyclovir solid dispersions with Pluronic F127 prepared by the kneading method |
| title_fullStr | Physicochemical characterization and dissolution studies of acyclovir solid dispersions with Pluronic F127 prepared by the kneading method |
| title_full_unstemmed | Physicochemical characterization and dissolution studies of acyclovir solid dispersions with Pluronic F127 prepared by the kneading method |
| title_short | Physicochemical characterization and dissolution studies of acyclovir solid dispersions with Pluronic F127 prepared by the kneading method |
| title_sort | physicochemical characterization and dissolution studies of acyclovir solid dispersions with pluronic f127 prepared by the kneading method |
| topic | acyclovir pluronic f127 solid dispersions physical mixtures kneading dissolution improvement |
| url | https://doi.org/10.1515/acph-2016-0008 |
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