Nocardiosis in a Kidney-Pancreas Transplant

34-year-old man with chronic renal and pancreas failure in complicated diabetic disease received a kidney-pancreas transplantation. On the 32nd postoperative day, an acute kidney rejection occurred and resolved with OKT3 therapy. The patient also presented refractory urinary infection by E. Fecalis...

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Main Authors: I. Fontana, G. Gasloli, A. Magoni Rossi, C. Bornacina, F. Dodi, M. Bertocchi, O. Soro, P. Diviacco, A. De Negri, E. Bocci, C. Ferrari, A. Giannone, Umberto Valente
Format: Article
Language:English
Published: Wiley 2010-01-01
Series:Journal of Transplantation
Online Access:http://dx.doi.org/10.1155/2010/573234
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author I. Fontana
G. Gasloli
A. Magoni Rossi
C. Bornacina
F. Dodi
M. Bertocchi
O. Soro
P. Diviacco
A. De Negri
E. Bocci
C. Ferrari
A. Giannone
Umberto Valente
author_facet I. Fontana
G. Gasloli
A. Magoni Rossi
C. Bornacina
F. Dodi
M. Bertocchi
O. Soro
P. Diviacco
A. De Negri
E. Bocci
C. Ferrari
A. Giannone
Umberto Valente
author_sort I. Fontana
collection DOAJ
description 34-year-old man with chronic renal and pancreas failure in complicated diabetic disease received a kidney-pancreas transplantation. On the 32nd postoperative day, an acute kidney rejection occurred and resolved with OKT3 therapy. The patient also presented refractory urinary infection by E. Fecalis and M. Morganii, and a focal bronchopneumonia in the right-basal lobe resolved with elective chemotherapy. During the 50th post-operative day, an intense soft tissue inflammation localized in the first left metatarsal-phalangeal articulation occurred (Figure 1) followed by an abscess with a cutaneous fistula and extension to the almost totality of foot area. The radiological exam revealed a small osteo-lacunar image localized in the proximal phalanx head of the first finger foot. From the cultural examination of the purulent material, N. Asteroides was identified. An amoxicillin-based treatment was started and continued for three months, with the complete resolution of infection This case is reported for its rarity in our casuistry, and for its difficult differential diagnosis with other potentially serious infections.
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spelling doaj-art-8f460fbd9a9e4393b86060568399a51b2025-02-03T01:33:18ZengWileyJournal of Transplantation2090-00072090-00152010-01-01201010.1155/2010/573234573234Nocardiosis in a Kidney-Pancreas TransplantI. Fontana0G. Gasloli1A. Magoni Rossi2C. Bornacina3F. Dodi4M. Bertocchi5O. Soro6P. Diviacco7A. De Negri8E. Bocci9C. Ferrari10A. Giannone11Umberto Valente12Department of Transplantation, San Martino University Hospital, L.go R. Benzi 10, 16132 Genoa, ItalyDepartment of Transplantation, San Martino University Hospital, L.go R. Benzi 10, 16132 Genoa, ItalyDepartment of Transplantation, San Martino University Hospital, L.go R. Benzi 10, 16132 Genoa, ItalyDepartment of Dermatology, University of Western Pindemont, via Solaroli 17, 28100 Novara, ItalyDepartment of Transplantation, San Martino University Hospital, L.go R. Benzi 10, 16132 Genoa, ItalyDepartment of Transplantation, San Martino University Hospital, L.go R. Benzi 10, 16132 Genoa, ItalyDepartment of Transplantation, San Martino University Hospital, L.go R. Benzi 10, 16132 Genoa, ItalyDepartment of Transplantation, San Martino University Hospital, L.go R. Benzi 10, 16132 Genoa, ItalyDepartment of Transplantation, San Martino University Hospital, L.go R. Benzi 10, 16132 Genoa, ItalyDepartment of Transplantation, San Martino University Hospital, L.go R. Benzi 10, 16132 Genoa, ItalyDepartment of Transplantation, San Martino University Hospital, L.go R. Benzi 10, 16132 Genoa, ItalyDepartment of Transplantation, San Martino University Hospital, L.go R. Benzi 10, 16132 Genoa, ItalyDepartment of Transplantation, San Martino University Hospital, L.go R. Benzi 10, 16132 Genoa, Italy34-year-old man with chronic renal and pancreas failure in complicated diabetic disease received a kidney-pancreas transplantation. On the 32nd postoperative day, an acute kidney rejection occurred and resolved with OKT3 therapy. The patient also presented refractory urinary infection by E. Fecalis and M. Morganii, and a focal bronchopneumonia in the right-basal lobe resolved with elective chemotherapy. During the 50th post-operative day, an intense soft tissue inflammation localized in the first left metatarsal-phalangeal articulation occurred (Figure 1) followed by an abscess with a cutaneous fistula and extension to the almost totality of foot area. The radiological exam revealed a small osteo-lacunar image localized in the proximal phalanx head of the first finger foot. From the cultural examination of the purulent material, N. Asteroides was identified. An amoxicillin-based treatment was started and continued for three months, with the complete resolution of infection This case is reported for its rarity in our casuistry, and for its difficult differential diagnosis with other potentially serious infections.http://dx.doi.org/10.1155/2010/573234
spellingShingle I. Fontana
G. Gasloli
A. Magoni Rossi
C. Bornacina
F. Dodi
M. Bertocchi
O. Soro
P. Diviacco
A. De Negri
E. Bocci
C. Ferrari
A. Giannone
Umberto Valente
Nocardiosis in a Kidney-Pancreas Transplant
Journal of Transplantation
title Nocardiosis in a Kidney-Pancreas Transplant
title_full Nocardiosis in a Kidney-Pancreas Transplant
title_fullStr Nocardiosis in a Kidney-Pancreas Transplant
title_full_unstemmed Nocardiosis in a Kidney-Pancreas Transplant
title_short Nocardiosis in a Kidney-Pancreas Transplant
title_sort nocardiosis in a kidney pancreas transplant
url http://dx.doi.org/10.1155/2010/573234
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