Bioengineering strategies targeting angiogenesis: Innovative solutions for osteonecrosis of the femoral head
Osteonecrosis of the femoral head (ONFH) is a prevalent orthopedic disorder characterized primarily by compromised blood supply. This vascular deficit results in cell apoptosis, trabecular bone loss, and structural collapse of the femoral head at late stage, significantly impairing joint function. W...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-01-01
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| Series: | Journal of Tissue Engineering |
| Online Access: | https://doi.org/10.1177/20417314241310541 |
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| _version_ | 1832586586901970944 |
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| author | Weihong Zhu Zhenmu Xu Ding Zhou Jiankun Xu Yuchen He Zhong Alan Li |
| author_facet | Weihong Zhu Zhenmu Xu Ding Zhou Jiankun Xu Yuchen He Zhong Alan Li |
| author_sort | Weihong Zhu |
| collection | DOAJ |
| description | Osteonecrosis of the femoral head (ONFH) is a prevalent orthopedic disorder characterized primarily by compromised blood supply. This vascular deficit results in cell apoptosis, trabecular bone loss, and structural collapse of the femoral head at late stage, significantly impairing joint function. While MRI is a highly effective tool for diagnosing ONFH in its early stages, challenges remain due to the limited availability and high cost of MRI, as well as the absence of routine MRI screening in asymptomatic patients. . In addition, current therapeutic strategies predominantly only relieve symptoms while disease-modifying ONFH drugs are still under investigation/development. Considering that blood supply of the femoral head plays a key role in the pathology of ONFH, angiogenic therapies have been put forward as promising treatment options. Emerging bioengineering interventions targeting angiogenesis hold promising potential for ONFH treatment. In this review, we introduce the advances in research into the pathology of ONFH and summarize novel bioengineering interventions targeting angiogenesis. This review sheds light upon new directions for future research into ONFH. |
| format | Article |
| id | doaj-art-8f419f1590924803a8ec925a9c205658 |
| institution | Kabale University |
| issn | 2041-7314 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Tissue Engineering |
| spelling | doaj-art-8f419f1590924803a8ec925a9c2056582025-01-25T07:03:37ZengSAGE PublishingJournal of Tissue Engineering2041-73142025-01-011610.1177/20417314241310541Bioengineering strategies targeting angiogenesis: Innovative solutions for osteonecrosis of the femoral headWeihong Zhu0Zhenmu Xu1Ding Zhou2Jiankun Xu3Yuchen He4Zhong Alan Li5Department of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDepartment of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDepartment of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaInnovative Orthopaedic Biomaterial and Drug Translational Research Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, ChinaDepartment of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaShenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, ChinaOsteonecrosis of the femoral head (ONFH) is a prevalent orthopedic disorder characterized primarily by compromised blood supply. This vascular deficit results in cell apoptosis, trabecular bone loss, and structural collapse of the femoral head at late stage, significantly impairing joint function. While MRI is a highly effective tool for diagnosing ONFH in its early stages, challenges remain due to the limited availability and high cost of MRI, as well as the absence of routine MRI screening in asymptomatic patients. . In addition, current therapeutic strategies predominantly only relieve symptoms while disease-modifying ONFH drugs are still under investigation/development. Considering that blood supply of the femoral head plays a key role in the pathology of ONFH, angiogenic therapies have been put forward as promising treatment options. Emerging bioengineering interventions targeting angiogenesis hold promising potential for ONFH treatment. In this review, we introduce the advances in research into the pathology of ONFH and summarize novel bioengineering interventions targeting angiogenesis. This review sheds light upon new directions for future research into ONFH.https://doi.org/10.1177/20417314241310541 |
| spellingShingle | Weihong Zhu Zhenmu Xu Ding Zhou Jiankun Xu Yuchen He Zhong Alan Li Bioengineering strategies targeting angiogenesis: Innovative solutions for osteonecrosis of the femoral head Journal of Tissue Engineering |
| title | Bioengineering strategies targeting angiogenesis: Innovative solutions for osteonecrosis of the femoral head |
| title_full | Bioengineering strategies targeting angiogenesis: Innovative solutions for osteonecrosis of the femoral head |
| title_fullStr | Bioengineering strategies targeting angiogenesis: Innovative solutions for osteonecrosis of the femoral head |
| title_full_unstemmed | Bioengineering strategies targeting angiogenesis: Innovative solutions for osteonecrosis of the femoral head |
| title_short | Bioengineering strategies targeting angiogenesis: Innovative solutions for osteonecrosis of the femoral head |
| title_sort | bioengineering strategies targeting angiogenesis innovative solutions for osteonecrosis of the femoral head |
| url | https://doi.org/10.1177/20417314241310541 |
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