Emodin promotes GSK-3β-mediated PD-L1 proteasomal degradation and enhances anti-tumor immunity in hepatocellular carcinoma

Emodin promotes GSK-3β-mediated PD-L1 proteasomal degradation and enhances anti-tumor immunity in hepatocellular carcinoma

Abstract Background Programmed death-ligand 1 (PD-L1), a prominent immune checkpoint, interacts with programmed death protein-1 (PD-1) on cytotoxic T cells within tumors and promotes immune evasion. Emodin, which is known to destabilize PD-L1 in breast cancer, has great potential for enhancing anti-...

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Main Authors: Xuemei Yang, Weiguang Chen, Haitao Sun, Weicong Chen, Wei Xu, Chunyu He, Yang Liu, Ying Kuang, Yanhao Ma, Binglian Zhong, Chaojie Li, Guohuan Li, Qingfeng Du, Songqi He
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Chinese Medicine
Subjects:
Hepatocellular carcinoma
Emodin
PD-L1
GSK-3β
Online Access:https://doi.org/10.1186/s13020-025-01146-6
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