Lung Function Abnormalities in Sickle Cell Anaemia
Background. Abnormalities in lung function tests have been shown to commonly occur in a majority of patients with sickle cell disease (SCD) even at steady state. The prevalence and pattern of these lung function abnormalities have been described in other populations but this is unknown among our sic...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2019/1783240 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556281919963136 |
|---|---|
| author | Yvonne A. Dei-Adomakoh Jane S. Afriyie-Mensah Audrey Forson Martin Adadey Thomas A. Ndanu Joseph K. Acquaye |
| author_facet | Yvonne A. Dei-Adomakoh Jane S. Afriyie-Mensah Audrey Forson Martin Adadey Thomas A. Ndanu Joseph K. Acquaye |
| author_sort | Yvonne A. Dei-Adomakoh |
| collection | DOAJ |
| description | Background. Abnormalities in lung function tests have been shown to commonly occur in a majority of patients with sickle cell disease (SCD) even at steady state. The prevalence and pattern of these lung function abnormalities have been described in other populations but this is unknown among our sickle cell cohort. There is generally little information available on risk factors associated with the lung function abnormalities and its relevance in patient care. Method. This was an analytical cross-sectional study involving 76 clinically stable, hydroxyurea-naive adult Hb-SS participants and 76 nonsickle cell disease (non-SCD) controls. A structured questionnaire was used to obtain sociodemographic data and clinical history of the participants. Investigations performed included spirometry, pulse oximetry, tricuspid regurgitant jet velocity (TRV) measurements via echocardiogram, complete blood counts, free plasma haemoglobin, serum urea, and creatinine. Results. Weight, BMI, mean FVC, and FEV1% predicted values were comparatively lower among the Hb-SS patients (p < 0.001). Abnormal spirometry outcome occurred in 70.4% of Hb-SS patients, predominantly restrictive defects (p < 0.001), and showed no significant association with steady-state Hb, WBC count, free plasma haemoglobin, frequency of sickling crisis, chronic leg ulcers, and TRV measurements (p > 0.05). The mean oxygen saturation was comparatively lower among Hb-SS patients (p < 0.001). Conclusion. Measured lung volumes were significantly lower in Hb-SS patients when compared to non-SCD controls and this difference was not influenced by anthropometric variance. Lung function abnormalities, particularly restrictive defects, are prevalent in Hb-SS patients but showed no significant association with recognized markers of disease severity. |
| format | Article |
| id | doaj-art-8f2b57ebb05a4303b93bb53c4f6d8904 |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-8f2b57ebb05a4303b93bb53c4f6d89042025-02-03T05:45:49ZengWileyAdvances in Hematology1687-91041687-91122019-01-01201910.1155/2019/17832401783240Lung Function Abnormalities in Sickle Cell AnaemiaYvonne A. Dei-Adomakoh0Jane S. Afriyie-Mensah1Audrey Forson2Martin Adadey3Thomas A. Ndanu4Joseph K. Acquaye5Department of Haematology, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, Accra, GhanaDepartment of Medicine and therapeutics, School of Medicine and Dentistry, College of Health Sciences, University of Ghana, Accra, GhanaDepartment of Medicine and therapeutics, School of Medicine and Dentistry, College of Health Sciences, University of Ghana, Accra, GhanaDepartment of Medicine and therapeutics, School of Medicine and Dentistry, College of Health Sciences, University of Ghana, Accra, GhanaDepartment of Community and Preventive Dentistry, School of Medicine and Dentistry, College of Health Sciences, University of Ghana, Accra, GhanaDepartment of Haematology, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, Accra, GhanaBackground. Abnormalities in lung function tests have been shown to commonly occur in a majority of patients with sickle cell disease (SCD) even at steady state. The prevalence and pattern of these lung function abnormalities have been described in other populations but this is unknown among our sickle cell cohort. There is generally little information available on risk factors associated with the lung function abnormalities and its relevance in patient care. Method. This was an analytical cross-sectional study involving 76 clinically stable, hydroxyurea-naive adult Hb-SS participants and 76 nonsickle cell disease (non-SCD) controls. A structured questionnaire was used to obtain sociodemographic data and clinical history of the participants. Investigations performed included spirometry, pulse oximetry, tricuspid regurgitant jet velocity (TRV) measurements via echocardiogram, complete blood counts, free plasma haemoglobin, serum urea, and creatinine. Results. Weight, BMI, mean FVC, and FEV1% predicted values were comparatively lower among the Hb-SS patients (p < 0.001). Abnormal spirometry outcome occurred in 70.4% of Hb-SS patients, predominantly restrictive defects (p < 0.001), and showed no significant association with steady-state Hb, WBC count, free plasma haemoglobin, frequency of sickling crisis, chronic leg ulcers, and TRV measurements (p > 0.05). The mean oxygen saturation was comparatively lower among Hb-SS patients (p < 0.001). Conclusion. Measured lung volumes were significantly lower in Hb-SS patients when compared to non-SCD controls and this difference was not influenced by anthropometric variance. Lung function abnormalities, particularly restrictive defects, are prevalent in Hb-SS patients but showed no significant association with recognized markers of disease severity.http://dx.doi.org/10.1155/2019/1783240 |
| spellingShingle | Yvonne A. Dei-Adomakoh Jane S. Afriyie-Mensah Audrey Forson Martin Adadey Thomas A. Ndanu Joseph K. Acquaye Lung Function Abnormalities in Sickle Cell Anaemia Advances in Hematology |
| title | Lung Function Abnormalities in Sickle Cell Anaemia |
| title_full | Lung Function Abnormalities in Sickle Cell Anaemia |
| title_fullStr | Lung Function Abnormalities in Sickle Cell Anaemia |
| title_full_unstemmed | Lung Function Abnormalities in Sickle Cell Anaemia |
| title_short | Lung Function Abnormalities in Sickle Cell Anaemia |
| title_sort | lung function abnormalities in sickle cell anaemia |
| url | http://dx.doi.org/10.1155/2019/1783240 |
| work_keys_str_mv | AT yvonneadeiadomakoh lungfunctionabnormalitiesinsicklecellanaemia AT janesafriyiemensah lungfunctionabnormalitiesinsicklecellanaemia AT audreyforson lungfunctionabnormalitiesinsicklecellanaemia AT martinadadey lungfunctionabnormalitiesinsicklecellanaemia AT thomasandanu lungfunctionabnormalitiesinsicklecellanaemia AT josephkacquaye lungfunctionabnormalitiesinsicklecellanaemia |