A secretome screen in primary human lung fibroblasts identifies FGF9 as a novel regulator of cellular senescence

A secretome screen in primary human lung fibroblasts identifies FGF9 as a novel regulator of cellular senescence

Senescent cells contribute to the pathogenesis of idiopathic pulmonary fibrosis (IPF), a disease with significant unmet need and therefore, there is an interest in discovering new drug targets that regulate this process. We design and perform a phenotypic screen with a secreted protein library in pr...

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Bibliographic Details
Main Authors: Jenna Bradley, Patrick O'Shea, Catherine Wrench, Johan Mattsson, Roxane Paulin, Catherine Overed-Sayer, Laura Rosenberg, Henric Olsson, Davide Gianni
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:SLAS Discovery
Subjects:
Senescence
Idiopathic pulmonary fibrosis
Phenotypic screen
FGF9
Fibroblasts
Online Access:http://www.sciencedirect.com/science/article/pii/S2472555225000164
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