PU.1 and Haematopoietic Cell Fate: Dosage Matters
The ETS family transcription factor PU.1 is a key regulator of haematopoietic differentiation. Its expression is dynamically controlled throughout haematopoiesis in order to direct appropriate lineage specification. Elucidating the biological role of PU.1 has proved challenging. This paper will disc...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2011/808524 |
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| _version_ | 1832558740177420288 |
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| author | Ka Sin Mak Alister P. W. Funnell Richard C. M. Pearson Merlin Crossley |
| author_facet | Ka Sin Mak Alister P. W. Funnell Richard C. M. Pearson Merlin Crossley |
| author_sort | Ka Sin Mak |
| collection | DOAJ |
| description | The ETS family transcription factor PU.1 is a key regulator of haematopoietic differentiation. Its expression is dynamically controlled throughout haematopoiesis in order to direct appropriate lineage specification. Elucidating the biological role of PU.1 has proved challenging. This paper will discuss how a range of experiments in cell lines and mutant and transgenic mouse models have enhanced our knowledge of the mechanisms by which PU.1 drives lineage-specific differentiation during haematopoiesis. |
| format | Article |
| id | doaj-art-8efa5967ac1d4078bc28579982e9904e |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-8efa5967ac1d4078bc28579982e9904e2025-02-03T01:31:45ZengWileyInternational Journal of Cell Biology1687-88761687-88842011-01-01201110.1155/2011/808524808524PU.1 and Haematopoietic Cell Fate: Dosage MattersKa Sin Mak0Alister P. W. Funnell1Richard C. M. Pearson2Merlin Crossley3School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, AustraliaSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, AustraliaSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, AustraliaSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, AustraliaThe ETS family transcription factor PU.1 is a key regulator of haematopoietic differentiation. Its expression is dynamically controlled throughout haematopoiesis in order to direct appropriate lineage specification. Elucidating the biological role of PU.1 has proved challenging. This paper will discuss how a range of experiments in cell lines and mutant and transgenic mouse models have enhanced our knowledge of the mechanisms by which PU.1 drives lineage-specific differentiation during haematopoiesis.http://dx.doi.org/10.1155/2011/808524 |
| spellingShingle | Ka Sin Mak Alister P. W. Funnell Richard C. M. Pearson Merlin Crossley PU.1 and Haematopoietic Cell Fate: Dosage Matters International Journal of Cell Biology |
| title | PU.1 and Haematopoietic Cell Fate: Dosage Matters |
| title_full | PU.1 and Haematopoietic Cell Fate: Dosage Matters |
| title_fullStr | PU.1 and Haematopoietic Cell Fate: Dosage Matters |
| title_full_unstemmed | PU.1 and Haematopoietic Cell Fate: Dosage Matters |
| title_short | PU.1 and Haematopoietic Cell Fate: Dosage Matters |
| title_sort | pu 1 and haematopoietic cell fate dosage matters |
| url | http://dx.doi.org/10.1155/2011/808524 |
| work_keys_str_mv | AT kasinmak pu1andhaematopoieticcellfatedosagematters AT alisterpwfunnell pu1andhaematopoieticcellfatedosagematters AT richardcmpearson pu1andhaematopoieticcellfatedosagematters AT merlincrossley pu1andhaematopoieticcellfatedosagematters |