Synthesis and Antimicrobial Activity of Some Aldehyde Derivatives of 3-Acetylchromen-2-one
Some new 3-(substituted)-chromen-2-one have been synthesized by condensation of 3-acetylchromen-2-one with various aromatic aldehyde in presence of ethanol and alkali. The synthesized compounds were identified by spectral data and screened for their antibacterial activity against B. pumilis, B. subs...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2010/937903 |
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| author | B. Lakshminarayanan V. Rajamanickam T. Subburaju L. A. Pradeep Rajkumar H. Revathi |
| author_facet | B. Lakshminarayanan V. Rajamanickam T. Subburaju L. A. Pradeep Rajkumar H. Revathi |
| author_sort | B. Lakshminarayanan |
| collection | DOAJ |
| description | Some new 3-(substituted)-chromen-2-one have been synthesized by condensation of 3-acetylchromen-2-one with various aromatic aldehyde in presence of ethanol and alkali. The synthesized compounds were identified by spectral data and screened for their antibacterial activity against B. pumilis, B. substilis and E. coli and antifungal activity against A. niger and Candida albicans. Among the synthesized compounds, some compounds of aryl chromen, which are having electron releasing substituent such as methoxy and hydroxyl at various positions, showed moderate to considerable antibacterial and antifungal activities. |
| format | Article |
| id | doaj-art-8ee6cbc3aa3347b2840baa97941633d8 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-8ee6cbc3aa3347b2840baa97941633d82025-02-03T01:28:01ZengWileyE-Journal of Chemistry0973-49452090-98102010-01-017S1S400S40410.1155/2010/937903Synthesis and Antimicrobial Activity of Some Aldehyde Derivatives of 3-Acetylchromen-2-oneB. Lakshminarayanan0V. Rajamanickam1T. Subburaju2L. A. Pradeep Rajkumar3H. Revathi4Karpagam College of Pharmacy , S.F.No:762, Othakkalmandapam, Coimbatore-641032, IndiaArulmigu Kalasalingam College of Pharmacy, Anand Nagar, Krishnankoil-626190, IndiaArulmigu Kalasalingam College of Pharmacy, Anand Nagar, Krishnankoil-626190, IndiaArulmigu Kalasalingam College of Pharmacy, Anand Nagar, Krishnankoil-626190, IndiaWockhardt Limited, Biotech Park, H-14/2 m.i.d.c. Area, Waluj, Aurangabad-431136, IndiaSome new 3-(substituted)-chromen-2-one have been synthesized by condensation of 3-acetylchromen-2-one with various aromatic aldehyde in presence of ethanol and alkali. The synthesized compounds were identified by spectral data and screened for their antibacterial activity against B. pumilis, B. substilis and E. coli and antifungal activity against A. niger and Candida albicans. Among the synthesized compounds, some compounds of aryl chromen, which are having electron releasing substituent such as methoxy and hydroxyl at various positions, showed moderate to considerable antibacterial and antifungal activities.http://dx.doi.org/10.1155/2010/937903 |
| spellingShingle | B. Lakshminarayanan V. Rajamanickam T. Subburaju L. A. Pradeep Rajkumar H. Revathi Synthesis and Antimicrobial Activity of Some Aldehyde Derivatives of 3-Acetylchromen-2-one E-Journal of Chemistry |
| title | Synthesis and Antimicrobial Activity of Some Aldehyde Derivatives of 3-Acetylchromen-2-one |
| title_full | Synthesis and Antimicrobial Activity of Some Aldehyde Derivatives of 3-Acetylchromen-2-one |
| title_fullStr | Synthesis and Antimicrobial Activity of Some Aldehyde Derivatives of 3-Acetylchromen-2-one |
| title_full_unstemmed | Synthesis and Antimicrobial Activity of Some Aldehyde Derivatives of 3-Acetylchromen-2-one |
| title_short | Synthesis and Antimicrobial Activity of Some Aldehyde Derivatives of 3-Acetylchromen-2-one |
| title_sort | synthesis and antimicrobial activity of some aldehyde derivatives of 3 acetylchromen 2 one |
| url | http://dx.doi.org/10.1155/2010/937903 |
| work_keys_str_mv | AT blakshminarayanan synthesisandantimicrobialactivityofsomealdehydederivativesof3acetylchromen2one AT vrajamanickam synthesisandantimicrobialactivityofsomealdehydederivativesof3acetylchromen2one AT tsubburaju synthesisandantimicrobialactivityofsomealdehydederivativesof3acetylchromen2one AT lapradeeprajkumar synthesisandantimicrobialactivityofsomealdehydederivativesof3acetylchromen2one AT hrevathi synthesisandantimicrobialactivityofsomealdehydederivativesof3acetylchromen2one |