Genome-level selection in tumors as a universal marker of resistance to therapy

Abstract Tumor evolution is shaped by selective pressures imposed by physiological factors as the tumor naturally progresses to colonize local and distant tissues, as well as by therapy. However, the distinction between these two types of pressures and their impact on tumor evolution remain elusive,...

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Bibliographic Details
Main Authors: Erez Persi, Praneeth R. Sudalagunta, Yuri I. Wolf, Rafael R. Canevarolo, Mehdi Damaghi, Kenneth H. Shain, Ariosto S. Silva, Eugene V. Koonin
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61709-x
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