Association between the Glu298Asp and T(-786)C polymorphisms of the endothelial nitric oxide synthase gene and respiratory distress in preterm neonates
Genetic polymorphisms in the gene that codes for endothelial nitric oxide synthase (eNOS) have been associated with less nitric oxide availability and with various cardiovascular diseases in humans. The objective of this study was to analyze the genotype distributions and allele frequencies f...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2010-04-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/4977 |
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| author | Ercan Sivasli Melih Babaoğlu Umit Yaşar Murat Yurdakök Atila Bozkurt Ayşe Korkmaz Sule Yiğit Gülsevin Tekinalp |
| author_facet | Ercan Sivasli Melih Babaoğlu Umit Yaşar Murat Yurdakök Atila Bozkurt Ayşe Korkmaz Sule Yiğit Gülsevin Tekinalp |
| author_sort | Ercan Sivasli |
| collection | DOAJ |
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Genetic polymorphisms in the gene that codes for endothelial nitric oxide synthase (eNOS) have been associated with less nitric oxide availability and with various cardiovascular diseases in humans. The objective of this study was to analyze the genotype distributions and allele frequencies for the Glu298Asp (G894T) and T(-786)C polymorphisms of the eNOS gene among neonates with respiratory distress in comparison to healthy control subjects. Fifty premature neonates with respiratory distress and 55 neonates without any respiratory problem were included in the study. Genomic DNA from all the neonates was analyzed by polymerase chain reaction. A polymerase chain reaction-restriction fragment length polymorphism analysis of eNOS gene polymorphisms was performed, and the results were compared. There were no significant differences between the groups regarding either genotype distributions or the allele frequencies for the Glu298Asp and T(-786)C polymorphisms. These results suggest that eNOS Glu298Asp and T(-786)C polymorphisms are not associated with development of respiratory distress.
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| format | Article |
| id | doaj-art-8ed7f4be11a24b0a83c76d9946aae7b8 |
| institution | OA Journals |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2010-04-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-8ed7f4be11a24b0a83c76d9946aae7b82025-08-20T02:01:53ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212010-04-01522Association between the Glu298Asp and T(-786)C polymorphisms of the endothelial nitric oxide synthase gene and respiratory distress in preterm neonatesErcan Sivasli0Melih BabaoğluUmit YaşarMurat YurdakökAtila BozkurtAyşe KorkmazSule YiğitGülsevin TekinalpDepartment of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey. Genetic polymorphisms in the gene that codes for endothelial nitric oxide synthase (eNOS) have been associated with less nitric oxide availability and with various cardiovascular diseases in humans. The objective of this study was to analyze the genotype distributions and allele frequencies for the Glu298Asp (G894T) and T(-786)C polymorphisms of the eNOS gene among neonates with respiratory distress in comparison to healthy control subjects. Fifty premature neonates with respiratory distress and 55 neonates without any respiratory problem were included in the study. Genomic DNA from all the neonates was analyzed by polymerase chain reaction. A polymerase chain reaction-restriction fragment length polymorphism analysis of eNOS gene polymorphisms was performed, and the results were compared. There were no significant differences between the groups regarding either genotype distributions or the allele frequencies for the Glu298Asp and T(-786)C polymorphisms. These results suggest that eNOS Glu298Asp and T(-786)C polymorphisms are not associated with development of respiratory distress. https://turkjpediatr.org/article/view/4977 |
| spellingShingle | Ercan Sivasli Melih Babaoğlu Umit Yaşar Murat Yurdakök Atila Bozkurt Ayşe Korkmaz Sule Yiğit Gülsevin Tekinalp Association between the Glu298Asp and T(-786)C polymorphisms of the endothelial nitric oxide synthase gene and respiratory distress in preterm neonates The Turkish Journal of Pediatrics |
| title | Association between the Glu298Asp and T(-786)C polymorphisms of the endothelial nitric oxide synthase gene and respiratory distress in preterm neonates |
| title_full | Association between the Glu298Asp and T(-786)C polymorphisms of the endothelial nitric oxide synthase gene and respiratory distress in preterm neonates |
| title_fullStr | Association between the Glu298Asp and T(-786)C polymorphisms of the endothelial nitric oxide synthase gene and respiratory distress in preterm neonates |
| title_full_unstemmed | Association between the Glu298Asp and T(-786)C polymorphisms of the endothelial nitric oxide synthase gene and respiratory distress in preterm neonates |
| title_short | Association between the Glu298Asp and T(-786)C polymorphisms of the endothelial nitric oxide synthase gene and respiratory distress in preterm neonates |
| title_sort | association between the glu298asp and t 786 c polymorphisms of the endothelial nitric oxide synthase gene and respiratory distress in preterm neonates |
| url | https://turkjpediatr.org/article/view/4977 |
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