Spatial deciphering of the transcriptomic heterogeneity of tumor spread through air spaces in lung cancer

Spatial deciphering of the transcriptomic heterogeneity of tumor spread through air spaces in lung cancer

BackgroundSpread through air spaces (STAS) represents a novel invasion mechanism in adenocarcinoma that considerably influences lung cancer clinical outcomes; however, studies of its mechanisms at the spatial level are lacking.MethodsWe used the NanoString GeoMx digital spatial profiling (DSP) techn...

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Bibliographic Details
Main Authors: Wenhao Wang, Wenhao Zhou, Jingli Fan, Tao Jiang, Guang Yang, Congcong Song, Siwei Xu, Haitao Luo, Huining Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
spread through air spaces
non-small-cell lung cancer
digital spatial profiling
spatial heterogeneity
spatial transcriptome
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1567527/full
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