Use of the Alpha-Glucosidase Inhibitor Acarbose in Patients with ‘Middleton Syndrome’: Normal Gastric Anatomy But with Accelerated Gastric Emptying Causing Postprandial Reactive Hypoglycemia and Diarrhea
Postprandial reactive hypoglycemia, early satiety and diarrhea are well-recognized side effects following full or partial gastrectomy or gastric bypass. It has only recently been realized, however, that patients with normal gastric anatomy may experience similar symptoms and signs due to primary acc...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2013/791803 |
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| author | Raymond J Playford Charlotte Pither Rui Gao Stephen J Middleton |
| author_facet | Raymond J Playford Charlotte Pither Rui Gao Stephen J Middleton |
| author_sort | Raymond J Playford |
| collection | DOAJ |
| description | Postprandial reactive hypoglycemia, early satiety and diarrhea are well-recognized side effects following full or partial gastrectomy or gastric bypass. It has only recently been realized, however, that patients with normal gastric anatomy may experience similar symptoms and signs due to primary accelerated gastric emptying (Middleton syndrome). In previous case studies, patients responded well to the use of dietary modification (frequent small-volume meals) alone. The authors describe two patients with this syndrome who continued to experience symptoms of reactive postprandial hypoglycemia despite dietary intervention but became asymptomatic following the addition of the alpha-glucosidase inhibitor acarbose. |
| format | Article |
| id | doaj-art-8eb39e20c7e9463bb3fb8e472ce17729 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-8eb39e20c7e9463bb3fb8e472ce177292025-02-03T06:44:31ZengWileyCanadian Journal of Gastroenterology0835-79002013-01-0127740340410.1155/2013/791803Use of the Alpha-Glucosidase Inhibitor Acarbose in Patients with ‘Middleton Syndrome’: Normal Gastric Anatomy But with Accelerated Gastric Emptying Causing Postprandial Reactive Hypoglycemia and DiarrheaRaymond J Playford0Charlotte Pither1Rui Gao2Stephen J Middleton3Office of the Vice Chancellor, Plymouth University, Plymouth, UKDepartment of Gastroenterology Addenbrooke’s, Cambridge University Teaching Hospital NHS Trust, Hills Road, Cambridge, UKDepartment of Gastroenterology Addenbrooke’s, Cambridge University Teaching Hospital NHS Trust, Hills Road, Cambridge, UKDepartment of Gastroenterology Addenbrooke’s, Cambridge University Teaching Hospital NHS Trust, Hills Road, Cambridge, UKPostprandial reactive hypoglycemia, early satiety and diarrhea are well-recognized side effects following full or partial gastrectomy or gastric bypass. It has only recently been realized, however, that patients with normal gastric anatomy may experience similar symptoms and signs due to primary accelerated gastric emptying (Middleton syndrome). In previous case studies, patients responded well to the use of dietary modification (frequent small-volume meals) alone. The authors describe two patients with this syndrome who continued to experience symptoms of reactive postprandial hypoglycemia despite dietary intervention but became asymptomatic following the addition of the alpha-glucosidase inhibitor acarbose.http://dx.doi.org/10.1155/2013/791803 |
| spellingShingle | Raymond J Playford Charlotte Pither Rui Gao Stephen J Middleton Use of the Alpha-Glucosidase Inhibitor Acarbose in Patients with ‘Middleton Syndrome’: Normal Gastric Anatomy But with Accelerated Gastric Emptying Causing Postprandial Reactive Hypoglycemia and Diarrhea Canadian Journal of Gastroenterology |
| title | Use of the Alpha-Glucosidase Inhibitor Acarbose in Patients with ‘Middleton Syndrome’: Normal Gastric Anatomy But with Accelerated Gastric Emptying Causing Postprandial Reactive Hypoglycemia and Diarrhea |
| title_full | Use of the Alpha-Glucosidase Inhibitor Acarbose in Patients with ‘Middleton Syndrome’: Normal Gastric Anatomy But with Accelerated Gastric Emptying Causing Postprandial Reactive Hypoglycemia and Diarrhea |
| title_fullStr | Use of the Alpha-Glucosidase Inhibitor Acarbose in Patients with ‘Middleton Syndrome’: Normal Gastric Anatomy But with Accelerated Gastric Emptying Causing Postprandial Reactive Hypoglycemia and Diarrhea |
| title_full_unstemmed | Use of the Alpha-Glucosidase Inhibitor Acarbose in Patients with ‘Middleton Syndrome’: Normal Gastric Anatomy But with Accelerated Gastric Emptying Causing Postprandial Reactive Hypoglycemia and Diarrhea |
| title_short | Use of the Alpha-Glucosidase Inhibitor Acarbose in Patients with ‘Middleton Syndrome’: Normal Gastric Anatomy But with Accelerated Gastric Emptying Causing Postprandial Reactive Hypoglycemia and Diarrhea |
| title_sort | use of the alpha glucosidase inhibitor acarbose in patients with middleton syndrome normal gastric anatomy but with accelerated gastric emptying causing postprandial reactive hypoglycemia and diarrhea |
| url | http://dx.doi.org/10.1155/2013/791803 |
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