Involvement of TSP1 and MMP9/NGAL in Angiogenesis during Orthodontic Periodontal Remodeling
In the present study the aim was to measure the levels of Thrombospondin-1 (TSP1) and Lipocalin-2/matrix metalloproteinase 9 (MMP9/NGAL) complex in gingival crevicular fluid (GCF) at different time points of orthodontic treatment, to determine the relationship between these values and those of total...
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| Format: | Article |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/421029 |
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| author | Petra Surlin Isabela Silosi Anne Marie Rauten Manole Cojocaru Lili Foia |
| author_facet | Petra Surlin Isabela Silosi Anne Marie Rauten Manole Cojocaru Lili Foia |
| author_sort | Petra Surlin |
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| description | In the present study the aim was to measure the levels of Thrombospondin-1 (TSP1) and Lipocalin-2/matrix metalloproteinase 9 (MMP9/NGAL) complex in gingival crevicular fluid (GCF) at different time points of orthodontic treatment, to determine the relationship between these values and those of total-matrix metalloproteinase 9 (MMP9) and theirs implication in angiogenesis balance, in the situation of a good control of the bacterial plaque, emphasizing the role of TSP1 and MMP9/NGAL complex. GCF samples were collected from 16 young orthodontic patients requiring upper canine distalization (test tooth) with first premolar extraction. The contralateral canine (control tooth) was free from orthodontic force. For the orthodontic appliance, brackets Roth 0.018 inch with 0.012 inch NiTi archwire and a laceback were used. TSP1, MMP9/NGAL, and MMP9 increased from 1 hour before activation of orthodontic appliance to a maximum at 8 hours for MMP9 and 72 hours for MMP9/NGAL and TSP1. The results show a change in time of TSP1, MMP9/NGAL, and MMP9 levels in GCF of patients with this method of orthodontic treatment. The powerful correlation of MMP9/NGAL with TSP1 suggests their stronger involvement in angiogenesis processes in PDL during orthodontic periodontal remodeling, in the situation of a healthy periodontium and a good control of the bacterial plaque. |
| format | Article |
| id | doaj-art-8e9e86fd4d0a423595124b5f7ba2a1da |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-8e9e86fd4d0a423595124b5f7ba2a1da2025-02-03T05:59:15ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/421029421029Involvement of TSP1 and MMP9/NGAL in Angiogenesis during Orthodontic Periodontal RemodelingPetra Surlin0Isabela Silosi1Anne Marie Rauten2Manole Cojocaru3Lili Foia4Department of Periodontology, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, RomaniaDepartment of Immunology, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, RomaniaDepartment of Orthodontics, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, RomaniaDepartment of Physiology, University of Medicine Titu Maiorescu of Bucharest, 187 Calea Vacaresti Street, 040051 Bucharest, RomaniaDepartment of Biochemistry, University of Medicine and Pharmacy “Gr. T. Popa” Iasi, 16 Universitatii Street, 700115 Iasi, RomaniaIn the present study the aim was to measure the levels of Thrombospondin-1 (TSP1) and Lipocalin-2/matrix metalloproteinase 9 (MMP9/NGAL) complex in gingival crevicular fluid (GCF) at different time points of orthodontic treatment, to determine the relationship between these values and those of total-matrix metalloproteinase 9 (MMP9) and theirs implication in angiogenesis balance, in the situation of a good control of the bacterial plaque, emphasizing the role of TSP1 and MMP9/NGAL complex. GCF samples were collected from 16 young orthodontic patients requiring upper canine distalization (test tooth) with first premolar extraction. The contralateral canine (control tooth) was free from orthodontic force. For the orthodontic appliance, brackets Roth 0.018 inch with 0.012 inch NiTi archwire and a laceback were used. TSP1, MMP9/NGAL, and MMP9 increased from 1 hour before activation of orthodontic appliance to a maximum at 8 hours for MMP9 and 72 hours for MMP9/NGAL and TSP1. The results show a change in time of TSP1, MMP9/NGAL, and MMP9 levels in GCF of patients with this method of orthodontic treatment. The powerful correlation of MMP9/NGAL with TSP1 suggests their stronger involvement in angiogenesis processes in PDL during orthodontic periodontal remodeling, in the situation of a healthy periodontium and a good control of the bacterial plaque.http://dx.doi.org/10.1155/2014/421029 |
| spellingShingle | Petra Surlin Isabela Silosi Anne Marie Rauten Manole Cojocaru Lili Foia Involvement of TSP1 and MMP9/NGAL in Angiogenesis during Orthodontic Periodontal Remodeling The Scientific World Journal |
| title | Involvement of TSP1 and MMP9/NGAL in Angiogenesis during Orthodontic Periodontal Remodeling |
| title_full | Involvement of TSP1 and MMP9/NGAL in Angiogenesis during Orthodontic Periodontal Remodeling |
| title_fullStr | Involvement of TSP1 and MMP9/NGAL in Angiogenesis during Orthodontic Periodontal Remodeling |
| title_full_unstemmed | Involvement of TSP1 and MMP9/NGAL in Angiogenesis during Orthodontic Periodontal Remodeling |
| title_short | Involvement of TSP1 and MMP9/NGAL in Angiogenesis during Orthodontic Periodontal Remodeling |
| title_sort | involvement of tsp1 and mmp9 ngal in angiogenesis during orthodontic periodontal remodeling |
| url | http://dx.doi.org/10.1155/2014/421029 |
| work_keys_str_mv | AT petrasurlin involvementoftsp1andmmp9ngalinangiogenesisduringorthodonticperiodontalremodeling AT isabelasilosi involvementoftsp1andmmp9ngalinangiogenesisduringorthodonticperiodontalremodeling AT annemarierauten involvementoftsp1andmmp9ngalinangiogenesisduringorthodonticperiodontalremodeling AT manolecojocaru involvementoftsp1andmmp9ngalinangiogenesisduringorthodonticperiodontalremodeling AT lilifoia involvementoftsp1andmmp9ngalinangiogenesisduringorthodonticperiodontalremodeling |