Biological properties and in silico studies of thiazolopyrimidine derivatives active against visceral and cutaneous Leishmania spp. amastigote forms

Biological properties and in silico studies of thiazolopyrimidine derivatives active against visceral and cutaneous Leishmania spp. amastigote forms

Visceral leishmaniasis, the most severe form of the disease, is caused by L. donovani and L. infantum parasites; cutaneous leishmaniasis is the most common endemic form of leishmaniasis and mainly caused by L. tropica and L. major. We have previously described a series of thiazolopyrimidine derivati...

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Bibliographic Details
Main Authors: Gulsah Bayraktar, Pascal Marchand, Euzébio Guimarães Barbosa, Marilia Cecilia da Silva, Karen Cacilda Weber, Sandrine Cojean, Merve Saylam, Huseyin Istanbullu
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:European Journal of Medicinal Chemistry Reports
Subjects:
Antileishmanial
Axenic amastigote
Intramacrophage amastigote
Thiazolopyrimidine
In silico studies
Online Access:http://www.sciencedirect.com/science/article/pii/S2772417424001006
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