Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging
Reactive oxygen species (ROS) are independently recognized to play a significant role in radiation-induced damage on healthy tissue and in aging process. However, an age-related alteration of antioxidant (AO) system in radiation response in humans is poorly investigated. The aim of this paper was to...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/982594 |
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| author | Jelena Kasapović Vesna Stojiljković Ljubica Gavrilović Nataša Popović Zorka Milićević |
| author_facet | Jelena Kasapović Vesna Stojiljković Ljubica Gavrilović Nataša Popović Zorka Milićević |
| author_sort | Jelena Kasapović |
| collection | DOAJ |
| description | Reactive oxygen species (ROS) are independently recognized to play a significant role in radiation-induced damage on healthy tissue and in aging process. However, an age-related alteration of antioxidant (AO) system in radiation response in humans is poorly investigated. The aim of this paper was to evaluate the irradiation effects on the activities and expression of AO system in the blood of healthy women during aging. Blood samples were irradiated with curative and palliative doses of 2 Gy or 9 Gy γ-rays. AO capacity for detoxification of O2•− and H2O2 in response to 2 Gy γ-irradiation decreases in women above 58 years, while in response to 9 Gy shows signs of weakening after 45 years of age. Due to reduction of AO capacity during aging, cytotoxic effects of curative and palliative doses of irradiation, mediated by ROS, may significantly increase in older subjects, while removal of H2O2 excess could reduce them. |
| format | Article |
| id | doaj-art-8e93ac2c0f244d829bb773434af18ff0 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-8e93ac2c0f244d829bb773434af18ff02025-02-03T01:27:33ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/982594982594Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with AgingJelena Kasapović0Vesna Stojiljković1Ljubica Gavrilović2Nataša Popović3Zorka Milićević4Laboratory of Molecular Biology and Endocrinology, Vinča Institute of Nuclear Sciences, University of Belgrade, Mike Petrovića Alasa 12-14, P.O. Box 522, 11 000 Belgrade, SerbiaLaboratory of Molecular Biology and Endocrinology, Vinča Institute of Nuclear Sciences, University of Belgrade, Mike Petrovića Alasa 12-14, P.O. Box 522, 11 000 Belgrade, SerbiaLaboratory of Molecular Biology and Endocrinology, Vinča Institute of Nuclear Sciences, University of Belgrade, Mike Petrovića Alasa 12-14, P.O. Box 522, 11 000 Belgrade, SerbiaLaboratory of Molecular Biology and Endocrinology, Vinča Institute of Nuclear Sciences, University of Belgrade, Mike Petrovića Alasa 12-14, P.O. Box 522, 11 000 Belgrade, SerbiaLaboratory of Molecular Biology and Endocrinology, Vinča Institute of Nuclear Sciences, University of Belgrade, Mike Petrovića Alasa 12-14, P.O. Box 522, 11 000 Belgrade, SerbiaReactive oxygen species (ROS) are independently recognized to play a significant role in radiation-induced damage on healthy tissue and in aging process. However, an age-related alteration of antioxidant (AO) system in radiation response in humans is poorly investigated. The aim of this paper was to evaluate the irradiation effects on the activities and expression of AO system in the blood of healthy women during aging. Blood samples were irradiated with curative and palliative doses of 2 Gy or 9 Gy γ-rays. AO capacity for detoxification of O2•− and H2O2 in response to 2 Gy γ-irradiation decreases in women above 58 years, while in response to 9 Gy shows signs of weakening after 45 years of age. Due to reduction of AO capacity during aging, cytotoxic effects of curative and palliative doses of irradiation, mediated by ROS, may significantly increase in older subjects, while removal of H2O2 excess could reduce them.http://dx.doi.org/10.1100/2012/982594 |
| spellingShingle | Jelena Kasapović Vesna Stojiljković Ljubica Gavrilović Nataša Popović Zorka Milićević Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging The Scientific World Journal |
| title | Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging |
| title_full | Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging |
| title_fullStr | Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging |
| title_full_unstemmed | Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging |
| title_short | Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging |
| title_sort | antioxidant protection against curative and palliative doses of ionizing irradiation in human blood decreases with aging |
| url | http://dx.doi.org/10.1100/2012/982594 |
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