Effect of neutrophils on tumor immunity and immunotherapy resistance with underlying mechanisms
Abstract Neutrophils are key mediators of the immune response and play essential roles in the development of tumors and immune evasion. Emerging studies indicate that neutrophils also play a critical role in the immunotherapy resistance in cancer. In this review, firstly, we summarize the novel clas...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
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| Series: | Cancer Communications |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cac2.12613 |
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| _version_ | 1832589711700393984 |
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| author | Jiali Yao Linlin Ji Guang Wang Jin Ding |
| author_facet | Jiali Yao Linlin Ji Guang Wang Jin Ding |
| author_sort | Jiali Yao |
| collection | DOAJ |
| description | Abstract Neutrophils are key mediators of the immune response and play essential roles in the development of tumors and immune evasion. Emerging studies indicate that neutrophils also play a critical role in the immunotherapy resistance in cancer. In this review, firstly, we summarize the novel classification and phenotypes of neutrophils and describe the regulatory relationships between neutrophils and tumor metabolism, flora microecology, neuroendocrine and tumor therapy from a new perspective. Secondly, we review the mechanisms by which neutrophils affect drug resistance in tumor immunotherapy from the aspects of the immune microenvironment, tumor antigens, and epigenetics. Finally, we propose several promising strategies for overcoming tumor immunotherapy resistance by targeting neutrophils and provide new research ideas in this area. |
| format | Article |
| id | doaj-art-8e7d00a2fa3b4473ad14872e1adc66ff |
| institution | Kabale University |
| issn | 2523-3548 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Communications |
| spelling | doaj-art-8e7d00a2fa3b4473ad14872e1adc66ff2025-01-24T09:09:47ZengWileyCancer Communications2523-35482025-01-01451154210.1002/cac2.12613Effect of neutrophils on tumor immunity and immunotherapy resistance with underlying mechanismsJiali Yao0Linlin Ji1Guang Wang2Jin Ding3Clinical Cancer Institute Center for Translational Medicine Naval Medical University Shanghai ChinaClinical Cancer Institute Center for Translational Medicine Naval Medical University Shanghai ChinaClinical Cancer Institute Center for Translational Medicine Naval Medical University Shanghai ChinaClinical Cancer Institute Center for Translational Medicine Naval Medical University Shanghai ChinaAbstract Neutrophils are key mediators of the immune response and play essential roles in the development of tumors and immune evasion. Emerging studies indicate that neutrophils also play a critical role in the immunotherapy resistance in cancer. In this review, firstly, we summarize the novel classification and phenotypes of neutrophils and describe the regulatory relationships between neutrophils and tumor metabolism, flora microecology, neuroendocrine and tumor therapy from a new perspective. Secondly, we review the mechanisms by which neutrophils affect drug resistance in tumor immunotherapy from the aspects of the immune microenvironment, tumor antigens, and epigenetics. Finally, we propose several promising strategies for overcoming tumor immunotherapy resistance by targeting neutrophils and provide new research ideas in this area.https://doi.org/10.1002/cac2.12613immune resistanceimmunotherapyneutrophiltumorTumor microenvironment |
| spellingShingle | Jiali Yao Linlin Ji Guang Wang Jin Ding Effect of neutrophils on tumor immunity and immunotherapy resistance with underlying mechanisms Cancer Communications immune resistance immunotherapy neutrophil tumor Tumor microenvironment |
| title | Effect of neutrophils on tumor immunity and immunotherapy resistance with underlying mechanisms |
| title_full | Effect of neutrophils on tumor immunity and immunotherapy resistance with underlying mechanisms |
| title_fullStr | Effect of neutrophils on tumor immunity and immunotherapy resistance with underlying mechanisms |
| title_full_unstemmed | Effect of neutrophils on tumor immunity and immunotherapy resistance with underlying mechanisms |
| title_short | Effect of neutrophils on tumor immunity and immunotherapy resistance with underlying mechanisms |
| title_sort | effect of neutrophils on tumor immunity and immunotherapy resistance with underlying mechanisms |
| topic | immune resistance immunotherapy neutrophil tumor Tumor microenvironment |
| url | https://doi.org/10.1002/cac2.12613 |
| work_keys_str_mv | AT jialiyao effectofneutrophilsontumorimmunityandimmunotherapyresistancewithunderlyingmechanisms AT linlinji effectofneutrophilsontumorimmunityandimmunotherapyresistancewithunderlyingmechanisms AT guangwang effectofneutrophilsontumorimmunityandimmunotherapyresistancewithunderlyingmechanisms AT jinding effectofneutrophilsontumorimmunityandimmunotherapyresistancewithunderlyingmechanisms |