Carbapenem treatment options for metallo-beta-lactamase: drug screening and dose optimization of meropenem-based combinations against NDM- or IMP-producing Klebsiella pneumoniae

Carbapenem treatment options for metallo-beta-lactamase: drug screening and dose optimization of meropenem-based combinations against NDM- or IMP-producing Klebsiella pneumoniae

BackgroundThe global dissemination of carbapenemase-producing Klebsiella pneumoniae (CPKP) has been occurring at an alarming pace, especially for the metallo-β-lactamase (MBL) group. Current clinical data suggest that carbapenem is still irreplaceable in terms of safety and efficacy. For MBL-produci...

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Bibliographic Details
Main Authors: Haoyue Che, Bo Hu, Xiaoming Cui, Jiyong Yang, Jinru Zeng, Liuhan Dong, Rui Wang, Yun Cai
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Microbiology
Subjects:
meropenem
fosfomycin
colistin (CST)
in vitro PK/PD model
MBL-KP
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1490372/full
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