Preoperative myosteatosis and perioperative serum chloride levels predict 180 day major complications after radical cystectomy
Abstract This study aimed to investigate the role of myosteatosis, sarcopenia, and perioperative serum biomarkers as independent predictors of major complications within 180 days following radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC). We retrospectively analyzed of 127 MIBC pati...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-87655-8 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832585927495516160 |
|---|---|
| author | Wassapol Sornthai Achiraya Teyateeti Tawatchai Taweemonkongsap Siros Jitpraphai Varat Woranisarakul Kantima Jongjitaree Katunyou Mahamongkol Nattaporn Wanvimolkul Thitipat Hansomwong |
| author_facet | Wassapol Sornthai Achiraya Teyateeti Tawatchai Taweemonkongsap Siros Jitpraphai Varat Woranisarakul Kantima Jongjitaree Katunyou Mahamongkol Nattaporn Wanvimolkul Thitipat Hansomwong |
| author_sort | Wassapol Sornthai |
| collection | DOAJ |
| description | Abstract This study aimed to investigate the role of myosteatosis, sarcopenia, and perioperative serum biomarkers as independent predictors of major complications within 180 days following radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC). We retrospectively analyzed of 127 MIBC patients who underwent RC between 2013 and 2023 at a single institution. Preoperative body composition was assessed using CT scans at the L3 vertebral level to measure psoas muscle density (PMD), skeletal muscle density (SMD), axial muscle density (AMD), and muscle indices. Novel inflammatory and nutritional markers, including serum chloride levels within 24 h post-surgery, were also evaluated. Major complications were defined as Clavien-Dindo grade ≥ 3. Multivariate analysis was performed to identify independent predictors of postoperative complications. Among the cohort, 30.7% of patients experienced major complications within 90 days, and 36.2% within 180 days. Sepsis was the most common major complication (19 of 241 complications, 7.9%). Ten patients died during the observation period. Myosteatosis (p = 0.002) and postoperative serum chloride levels (p < 0.001) were significant independent predictors of 180-day major complications. Patients with low PMD had an adjusted odds ratio (OR) of 3.959 for developing major complications, while increased serum chloride levels were associated with a reduced risk of complications (OR = 0.985). Multivariate analysis reveals associations between myosteatosis, aging, and anemia. Myosteatosis and perioperative serum chloride levels are significant predictors of major complications after RC for MIBC. Incorporating body composition analysis and early serum chloride monitoring into perioperative care may improve risk stratification and patient outcomes following RC. |
| format | Article |
| id | doaj-art-8e7216bc963b4a1680643c699918e385 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-8e7216bc963b4a1680643c699918e3852025-01-26T12:23:38ZengNature PortfolioScientific Reports2045-23222025-01-0115111210.1038/s41598-025-87655-8Preoperative myosteatosis and perioperative serum chloride levels predict 180 day major complications after radical cystectomyWassapol Sornthai0Achiraya Teyateeti1Tawatchai Taweemonkongsap2Siros Jitpraphai3Varat Woranisarakul4Kantima Jongjitaree5Katunyou Mahamongkol6Nattaporn Wanvimolkul7Thitipat Hansomwong8Division of Urology, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Radiation Oncology, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDivision of Urology, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDivision of Urology, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDivision of Urology, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDivision of Urology, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDivision of Urology, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDivision of Urology, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDivision of Urology, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol UniversityAbstract This study aimed to investigate the role of myosteatosis, sarcopenia, and perioperative serum biomarkers as independent predictors of major complications within 180 days following radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC). We retrospectively analyzed of 127 MIBC patients who underwent RC between 2013 and 2023 at a single institution. Preoperative body composition was assessed using CT scans at the L3 vertebral level to measure psoas muscle density (PMD), skeletal muscle density (SMD), axial muscle density (AMD), and muscle indices. Novel inflammatory and nutritional markers, including serum chloride levels within 24 h post-surgery, were also evaluated. Major complications were defined as Clavien-Dindo grade ≥ 3. Multivariate analysis was performed to identify independent predictors of postoperative complications. Among the cohort, 30.7% of patients experienced major complications within 90 days, and 36.2% within 180 days. Sepsis was the most common major complication (19 of 241 complications, 7.9%). Ten patients died during the observation period. Myosteatosis (p = 0.002) and postoperative serum chloride levels (p < 0.001) were significant independent predictors of 180-day major complications. Patients with low PMD had an adjusted odds ratio (OR) of 3.959 for developing major complications, while increased serum chloride levels were associated with a reduced risk of complications (OR = 0.985). Multivariate analysis reveals associations between myosteatosis, aging, and anemia. Myosteatosis and perioperative serum chloride levels are significant predictors of major complications after RC for MIBC. Incorporating body composition analysis and early serum chloride monitoring into perioperative care may improve risk stratification and patient outcomes following RC.https://doi.org/10.1038/s41598-025-87655-8MyosteatosisSkeletal muscleCystectomySerum chloridesPostoperative complications |
| spellingShingle | Wassapol Sornthai Achiraya Teyateeti Tawatchai Taweemonkongsap Siros Jitpraphai Varat Woranisarakul Kantima Jongjitaree Katunyou Mahamongkol Nattaporn Wanvimolkul Thitipat Hansomwong Preoperative myosteatosis and perioperative serum chloride levels predict 180 day major complications after radical cystectomy Scientific Reports Myosteatosis Skeletal muscle Cystectomy Serum chlorides Postoperative complications |
| title | Preoperative myosteatosis and perioperative serum chloride levels predict 180 day major complications after radical cystectomy |
| title_full | Preoperative myosteatosis and perioperative serum chloride levels predict 180 day major complications after radical cystectomy |
| title_fullStr | Preoperative myosteatosis and perioperative serum chloride levels predict 180 day major complications after radical cystectomy |
| title_full_unstemmed | Preoperative myosteatosis and perioperative serum chloride levels predict 180 day major complications after radical cystectomy |
| title_short | Preoperative myosteatosis and perioperative serum chloride levels predict 180 day major complications after radical cystectomy |
| title_sort | preoperative myosteatosis and perioperative serum chloride levels predict 180 day major complications after radical cystectomy |
| topic | Myosteatosis Skeletal muscle Cystectomy Serum chlorides Postoperative complications |
| url | https://doi.org/10.1038/s41598-025-87655-8 |
| work_keys_str_mv | AT wassapolsornthai preoperativemyosteatosisandperioperativeserumchloridelevelspredict180daymajorcomplicationsafterradicalcystectomy AT achirayateyateeti preoperativemyosteatosisandperioperativeserumchloridelevelspredict180daymajorcomplicationsafterradicalcystectomy AT tawatchaitaweemonkongsap preoperativemyosteatosisandperioperativeserumchloridelevelspredict180daymajorcomplicationsafterradicalcystectomy AT sirosjitpraphai preoperativemyosteatosisandperioperativeserumchloridelevelspredict180daymajorcomplicationsafterradicalcystectomy AT varatworanisarakul preoperativemyosteatosisandperioperativeserumchloridelevelspredict180daymajorcomplicationsafterradicalcystectomy AT kantimajongjitaree preoperativemyosteatosisandperioperativeserumchloridelevelspredict180daymajorcomplicationsafterradicalcystectomy AT katunyoumahamongkol preoperativemyosteatosisandperioperativeserumchloridelevelspredict180daymajorcomplicationsafterradicalcystectomy AT nattapornwanvimolkul preoperativemyosteatosisandperioperativeserumchloridelevelspredict180daymajorcomplicationsafterradicalcystectomy AT thitipathansomwong preoperativemyosteatosisandperioperativeserumchloridelevelspredict180daymajorcomplicationsafterradicalcystectomy |