Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits

Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits

Abstract Here, we present a multi-omics study of type 2 diabetes and quantitative blood lipid and lipoprotein traits conducted to date in Hispanic/Latino populations (nmax = 63,184). We conduct a meta-analysis of 16 type 2 diabetes and 19 lipid trait GWAS, identifying 20 genome-wide significant loci...

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Main Authors: Lauren E. Petty, Hung-Hsin Chen, Elizabeth G. Frankel, Wanying Zhu, Carolina G. Downie, Mariaelisa Graff, Phillip Lin, Priya Sharma, Xinruo Zhang, Alyssa C. Scartozzi, Rashedeh Roshani, Joshua M. Landman, Michael Boehnke, Donald W. Bowden, John C. Chambers, Anubha Mahajan, Mark I. McCarthy, Maggie C. Y. Ng, Xueling Sim, Cassandra N. Spracklen, Weihua Zhang, Michael Preuss, Erwin P. Bottinger, Girish N. Nadkarni, Ruth J. F. Loos, Yii-Der Ida Chen, Jingyi Tan, Eli Ipp, Pauline Genter, Leslie S. Emery, Tin Louie, Tamar Sofer, Adrienne M. Stilp, Kent D. Taylor, Anny H. Xiang, Thomas A. Buchanan, Kathryn Roll, Chuan Gao, Nicholette D. Palmer, Jill M. Norris, Lynne E. Wagenknecht, Darryl Nousome, Rohit Varma, Roberta McKean-Cowdin, Xiuqing Guo, Yang Hai, Willa Hsueh, Kevin Sandow, Esteban J. Parra, Miguel Cruz, Adan Valladares-Salgado, Niels Wacher-Rodarte, Jerome I. Rotter, Mark O. Goodarzi, Stephen S. Rich, Alain Bertoni, Leslie J. Raffel, Jerry L. Nadler, Fouad R. Kandeel, Ravindranath Duggirala, John Blangero, Donna M. Lehman, Ralph A. DeFronzo, Farook Thameem, Yujie Wang, Sheila Gahagan, Estela Blanco, Raquel Burrows, Alicia Huerta-Chagoya, Jose C. Florez, Teresa Tusie-Luna, Clicerio González-Villalpando, Lorena Orozco, Christopher A. Haiman, Craig L. Hanis, Rebecca Rohde, Eric A. Whitsel, Alexander P. Reiner, Charles Kooperberg, Yun Li, Qing Duan, Miryoung Lee, Paulina Correa-Burrows, Susan K. Fried, Kari E. North, Joseph B. McCormick, Susan P. Fisher-Hoch, Eric R. Gamazon, Andrew P. Morris, Josep M. Mercader, Heather M. Highland, Jennifer E. Below, On behalf of the DIAMANTE Hispanic/Latino Consortium, Global Hispanic Lipids Consortium
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58574-z
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Summary:Abstract Here, we present a multi-omics study of type 2 diabetes and quantitative blood lipid and lipoprotein traits conducted to date in Hispanic/Latino populations (nmax = 63,184). We conduct a meta-analysis of 16 type 2 diabetes and 19 lipid trait GWAS, identifying 20 genome-wide significant loci for type 2 diabetes, including one novel locus and novel signals at two known loci, based on fine-mapping. We also identify sixty-one genome-wide significant loci across the lipid/lipoprotein traits, including nine novel loci, and novel signals at 19 known loci through fine-mapping. Next, we analyze genetically regulated expression, perform Mendelian randomization, and analyze association with transcriptomic and proteomic measure using multi-omics data from a Hispanic/Latino population. Using this approach, we identify genes linked to type 2 diabetes and lipid/lipoprotein traits, including TMEM205 and NEDD9 for HDL cholesterol, TREH for triglycerides, and ANXA4 for type 2 diabetes.
ISSN:2041-1723

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