Serum Leptin Is not a Diagnostic Marker for Familial Mediterranean Fever Attacks
The aim of our study is to determine whether there is a relationship between familial Mediterranean fever (FMF) attacks and serum leptin levels. We enrolled 25 patients (22 males and 3 females) and 25 healthy controls (21 males and 4 females) with a mean age of 24.42±1.22 (Mean ± SEM) years and 24.3...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/62868 |
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| author | Bülent Toy Orhan Tarçın Sait Bağcı Yücel Üstündağ Ali Inal Arzu Tiftikçi |
| author_facet | Bülent Toy Orhan Tarçın Sait Bağcı Yücel Üstündağ Ali Inal Arzu Tiftikçi |
| author_sort | Bülent Toy |
| collection | DOAJ |
| description | The aim of our study is to determine whether there is a relationship between familial Mediterranean fever (FMF) attacks and serum leptin levels. We enrolled 25 patients (22 males and 3 females) and 25 healthy controls (21 males and 4 females) with a mean age of 24.42±1.22 (Mean ± SEM) years and 24.30±1.19 years (Mean ± SEM), respectively. We investigated serum levels of leptin, interleukin-6 (IL-6) erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), fibrinogen, and leukocyte counts before the attack and 8–12 hours after the attack started. The same parameters have been investigated in the control subjects. The mean serum leptin levels before the attacks were 6.45±1.05 (Mean ± SEM) and during the attacks were 7.59±1.3 (Mean ± SEM) in FMF group, respectively. There was a slight increase in serum leptin levels during the attacks but it was not statistically significant (P>.05). The mean serum leptin levels were 6.12±2.81 in the control group which were not different from the mean serum leptin levels before and during the attack periods in the study group (P>.05). However, there were statistical differences in the serum levels of IL-6, ESR, CRP, fibrinogen, and leukocyte counts before and during the attack periods (P<.05). No correlation was found between serum leptin levels and IL-6, ESR, CRP, fibrinogen, and leukocyte counts (P>.05). Serum leptin levels do not increase during FMF attacks and therefore it is not useful for diagnostic purposes and follow-up during treatment. |
| format | Article |
| id | doaj-art-8e631f20275f463db421492f7344b604 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-8e631f20275f463db421492f7344b6042025-02-03T01:22:06ZengWileyMediators of Inflammation0962-93511466-18612006-01-01200610.1155/MI/2006/6286862868Serum Leptin Is not a Diagnostic Marker for Familial Mediterranean Fever AttacksBülent Toy0Orhan Tarçın1Sait Bağcı2Yücel Üstündağ3Ali Inal4Arzu Tiftikçi5Department of Gastroenterology, Gülhane Military Medical Academy, Ankara 06018, TurkeyDivision of Gastroenterology, Gümücşuyu Military Hospital, İstanbul 34347, TurkeyDepartment of Gastroenterology, Gülhane Military Medical Academy, Ankara 06018, TurkeyDivision of Gastroenterology, Karaelmas University, Zonguldak 67100, TurkeyDepartment of Immunology, Gülhane Military Medical Academy, Ankara 06018, TurkeyDepartment of Gastroenterology, Marmara University, Kadiköy, İstanbul 34662, TurkeyThe aim of our study is to determine whether there is a relationship between familial Mediterranean fever (FMF) attacks and serum leptin levels. We enrolled 25 patients (22 males and 3 females) and 25 healthy controls (21 males and 4 females) with a mean age of 24.42±1.22 (Mean ± SEM) years and 24.30±1.19 years (Mean ± SEM), respectively. We investigated serum levels of leptin, interleukin-6 (IL-6) erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), fibrinogen, and leukocyte counts before the attack and 8–12 hours after the attack started. The same parameters have been investigated in the control subjects. The mean serum leptin levels before the attacks were 6.45±1.05 (Mean ± SEM) and during the attacks were 7.59±1.3 (Mean ± SEM) in FMF group, respectively. There was a slight increase in serum leptin levels during the attacks but it was not statistically significant (P>.05). The mean serum leptin levels were 6.12±2.81 in the control group which were not different from the mean serum leptin levels before and during the attack periods in the study group (P>.05). However, there were statistical differences in the serum levels of IL-6, ESR, CRP, fibrinogen, and leukocyte counts before and during the attack periods (P<.05). No correlation was found between serum leptin levels and IL-6, ESR, CRP, fibrinogen, and leukocyte counts (P>.05). Serum leptin levels do not increase during FMF attacks and therefore it is not useful for diagnostic purposes and follow-up during treatment.http://dx.doi.org/10.1155/MI/2006/62868 |
| spellingShingle | Bülent Toy Orhan Tarçın Sait Bağcı Yücel Üstündağ Ali Inal Arzu Tiftikçi Serum Leptin Is not a Diagnostic Marker for Familial Mediterranean Fever Attacks Mediators of Inflammation |
| title | Serum Leptin Is not a Diagnostic Marker for Familial Mediterranean Fever Attacks |
| title_full | Serum Leptin Is not a Diagnostic Marker for Familial Mediterranean Fever Attacks |
| title_fullStr | Serum Leptin Is not a Diagnostic Marker for Familial Mediterranean Fever Attacks |
| title_full_unstemmed | Serum Leptin Is not a Diagnostic Marker for Familial Mediterranean Fever Attacks |
| title_short | Serum Leptin Is not a Diagnostic Marker for Familial Mediterranean Fever Attacks |
| title_sort | serum leptin is not a diagnostic marker for familial mediterranean fever attacks |
| url | http://dx.doi.org/10.1155/MI/2006/62868 |
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