Three-Dimensional Modeling of <i>Camelus dromedarius</i> T Cell Receptor Gamma (TRG)_Delta (TRD)/CD1D Complex Reveals Different Binding Interactions Depending on the TRD CDR3 Length

Three-Dimensional Modeling of <i>Camelus dromedarius</i> T Cell Receptor Gamma (TRG)_Delta (TRD)/CD1D Complex Reveals Different Binding Interactions Depending on the TRD CDR3 Length

Background: In the adaptive immune response of the dromedary (<i>Camelus dromedarius</i>, Camdro), the T cell receptor (TR) repertoire of the gamma–delta (γδ) T cells is unusually diversified both by somatic hypermutation in rearranged TR gamma (TRG) and delta (TRD) genes and by the dive...

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Bibliographic Details
Main Authors: Salvatrice Ciccarese, Marie-Paule Lefranc, Giulia C. M. Perrone, Pietro D’Addabbo, Ciro Leonardo Pierri
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Antibodies
Subjects:
T cell receptor
<i>Camelus dromedarius</i>
TRG and TRD loci
multiple sequence alignments (MSA)
3D modeling
protein–protein interaction
Online Access:https://www.mdpi.com/2073-4468/14/2/46
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https://www.mdpi.com/2073-4468/14/2/46

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