High ovarian hormones present during fear extinction reduce fear relapse through a nigrostriatal dopamine pathway

High ovarian hormones present during fear extinction reduce fear relapse through a nigrostriatal dopamine pathway

Abstract Background Elevated ovarian hormones during fear extinction can enhance fear extinction memory retention and reduce fear renewal, but the mechanisms remain unknown. High levels of ovarian hormones are associated with heightened dopamine (DA) transmission, a key player in fear extinction. In...

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Main Authors: Alyssa A. Hohorst, Margaret K. Tanner, Rebecca Han, Kamryn M. Korth, Jessica D. Westerman, Carolina Sanchez Mendoza, Miles Q. Dryden, Lareina A. Alvarez, Remla A. Abdul, Esteban C. Loetz, Erik B. Oleson, Benjamin N. Greenwood
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Biology of Sex Differences
Subjects:
Estrous cycle
Estrogen
Dopamine
Fear extinction
Fear renewal
Spontaneous recovery
Online Access:https://doi.org/10.1186/s13293-025-00722-7
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https://doi.org/10.1186/s13293-025-00722-7

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