Clinico-Haematological Profile of Acute Megakaryoblastic Leukaemia: Report of Five Cases
Acute megakaryoblastic leukemia (AMKL) is a rare subtype of acute myeloid leukemia. Although known as a distinct entity for a very long time, because of lack of distinct clinical features and morphological criteria, it is difficult to diagnose this variant correctly. We herein present the clinical,...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2009/461912 |
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| author | Sunita Sharma Anita Nangia Sonal Jain Malhotra Shashi Narayan Aparna Harbhajanka Sarika Singh |
| author_facet | Sunita Sharma Anita Nangia Sonal Jain Malhotra Shashi Narayan Aparna Harbhajanka Sarika Singh |
| author_sort | Sunita Sharma |
| collection | DOAJ |
| description | Acute megakaryoblastic leukemia (AMKL) is a rare subtype of acute myeloid leukemia. Although known as a distinct entity for a very long time, because of lack of distinct clinical features and morphological criteria, it is difficult to diagnose this variant correctly. We herein present the clinical, morphological, cytochemical, and immunocytochemical features of five cases of AMKL. Certain morphological features such as presence of abnormal platelet count, giant platelets, and cytoplasmic blebbing in blasts were found to be important pointers towards the diagnosis. However, none of the features were found to be consistent and thus morphological diagnosis has to be confirmed by cytochemistry and immunocytochemistry. |
| format | Article |
| id | doaj-art-8e4b29d71327413cb74cb0d1e944fb74 |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-8e4b29d71327413cb74cb0d1e944fb742025-02-03T06:05:38ZengWileyAdvances in Hematology1687-91041687-91122009-01-01200910.1155/2009/461912461912Clinico-Haematological Profile of Acute Megakaryoblastic Leukaemia: Report of Five CasesSunita Sharma0Anita Nangia1Sonal Jain Malhotra2Shashi Narayan3Aparna Harbhajanka4Sarika Singh5Department of Pathology, Lady Hardinge Medical College, New Delhi 110001, IndiaDepartment of Pathology, Lady Hardinge Medical College, New Delhi 110001, IndiaDepartment of Pathology, Lady Hardinge Medical College, New Delhi 110001, IndiaDepartment of Pathology, Lady Hardinge Medical College, New Delhi 110001, IndiaDepartment of Pathology, Lady Hardinge Medical College, New Delhi 110001, IndiaDepartment of Pathology, Lady Hardinge Medical College, New Delhi 110001, IndiaAcute megakaryoblastic leukemia (AMKL) is a rare subtype of acute myeloid leukemia. Although known as a distinct entity for a very long time, because of lack of distinct clinical features and morphological criteria, it is difficult to diagnose this variant correctly. We herein present the clinical, morphological, cytochemical, and immunocytochemical features of five cases of AMKL. Certain morphological features such as presence of abnormal platelet count, giant platelets, and cytoplasmic blebbing in blasts were found to be important pointers towards the diagnosis. However, none of the features were found to be consistent and thus morphological diagnosis has to be confirmed by cytochemistry and immunocytochemistry.http://dx.doi.org/10.1155/2009/461912 |
| spellingShingle | Sunita Sharma Anita Nangia Sonal Jain Malhotra Shashi Narayan Aparna Harbhajanka Sarika Singh Clinico-Haematological Profile of Acute Megakaryoblastic Leukaemia: Report of Five Cases Advances in Hematology |
| title | Clinico-Haematological Profile of Acute Megakaryoblastic Leukaemia: Report of Five Cases |
| title_full | Clinico-Haematological Profile of Acute Megakaryoblastic Leukaemia: Report of Five Cases |
| title_fullStr | Clinico-Haematological Profile of Acute Megakaryoblastic Leukaemia: Report of Five Cases |
| title_full_unstemmed | Clinico-Haematological Profile of Acute Megakaryoblastic Leukaemia: Report of Five Cases |
| title_short | Clinico-Haematological Profile of Acute Megakaryoblastic Leukaemia: Report of Five Cases |
| title_sort | clinico haematological profile of acute megakaryoblastic leukaemia report of five cases |
| url | http://dx.doi.org/10.1155/2009/461912 |
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