Unveiling the Anti-Angiogenic Potential of Small-Molecule (Kinase) Inhibitors for Application in Rheumatoid Arthritis

Unveiling the Anti-Angiogenic Potential of Small-Molecule (Kinase) Inhibitors for Application in Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation leading to joint damage and systemic complications. Angiogenesis promotes inflammation and contributes to RA progression. This study evaluated potential anti-angiogenic effects of several compounds including smal...

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Bibliographic Details
Main Authors: Fatemeh Khodadust, Eva M. L. Philippon, Maarten M. Steinz, Jan Piet van Hamburg, Johan van Meerloo, Judy R. van Beijnum, Gerrit Jansen, Sander W. Tas, Conny J. van der Laken
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Cells
Subjects:
angiogenesis
rheumatoid arthritis
3D model
spheroid
small-molecule inhibitors
endothelial cells
Online Access:https://www.mdpi.com/2073-4409/14/2/102
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