Is the Juice Worth the Squeeze? Evaluating Peptide Nucleic Acid Blockers for Reducing Plant DNA Contamination in 16S rRNA Gene Sequencing

Next-generation sequencing of microbial communities frequently results in off-target amplification of the host or environmental DNA, which can lead to substantial data loss. This challenge is particularly pronounced in plant-associated microbiome studies, in which commonly used 16S rRNA primers co-a...

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Bibliographic Details
Main Authors: Lena Flörl, Nicholas A. Bokulich
Format: Article
Language:English
Published: The American Phytopathological Society 2025-03-01
Series:PhytoFrontiers
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Online Access:https://apsjournals.apsnet.org/doi/10.1094/PHYTOFR-11-24-0124-SC
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