A Retrospective on Nuclear Receptor Regulation of Inflammation: Lessons from GR and PPARs
Members of the nuclear receptor superfamily have vital roles in regulating immunity and inflammation. The founding member, glucocorticoid receptor (GR), is the prototype to demonstrate immunomodulation via transrepression of the AP-1 and NF-κB signaling pathways. Peroxisome proliferator-activated...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2011/742785 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832559913467904000 |
|---|---|
| author | Min-Dian Li Xiaoyong Yang |
| author_facet | Min-Dian Li Xiaoyong Yang |
| author_sort | Min-Dian Li |
| collection | DOAJ |
| description | Members of the nuclear receptor superfamily have vital roles in regulating immunity and inflammation. The founding member, glucocorticoid receptor (GR), is the prototype to demonstrate immunomodulation via transrepression of the AP-1 and NF-κB signaling pathways. Peroxisome proliferator-activated receptors (PPARs) have emerged as key regulators of inflammation. This review examines the history and current advances in nuclear receptor regulation of inflammation by the crosstalk with AP-1 and NF-κB signaling, focusing on the roles of GR and PPARs. A better understanding of the molecular mechanism by which nuclear receptors inhibit proinflammatory signaling pathways will enable novel therapies to treat chronic inflammation. |
| format | Article |
| id | doaj-art-8e428266a5cd449ebbf3ffdead24da55 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-8e428266a5cd449ebbf3ffdead24da552025-02-03T01:29:00ZengWileyPPAR Research1687-47571687-47652011-01-01201110.1155/2011/742785742785A Retrospective on Nuclear Receptor Regulation of Inflammation: Lessons from GR and PPARsMin-Dian Li0Xiaoyong Yang1Department of Cellular and Molecular Physiology, School of Medicine, Yale University, New Haven, CT, USADepartment of Cellular and Molecular Physiology, School of Medicine, Yale University, New Haven, CT, USAMembers of the nuclear receptor superfamily have vital roles in regulating immunity and inflammation. The founding member, glucocorticoid receptor (GR), is the prototype to demonstrate immunomodulation via transrepression of the AP-1 and NF-κB signaling pathways. Peroxisome proliferator-activated receptors (PPARs) have emerged as key regulators of inflammation. This review examines the history and current advances in nuclear receptor regulation of inflammation by the crosstalk with AP-1 and NF-κB signaling, focusing on the roles of GR and PPARs. A better understanding of the molecular mechanism by which nuclear receptors inhibit proinflammatory signaling pathways will enable novel therapies to treat chronic inflammation.http://dx.doi.org/10.1155/2011/742785 |
| spellingShingle | Min-Dian Li Xiaoyong Yang A Retrospective on Nuclear Receptor Regulation of Inflammation: Lessons from GR and PPARs PPAR Research |
| title | A Retrospective on Nuclear Receptor Regulation of Inflammation: Lessons from GR and PPARs |
| title_full | A Retrospective on Nuclear Receptor Regulation of Inflammation: Lessons from GR and PPARs |
| title_fullStr | A Retrospective on Nuclear Receptor Regulation of Inflammation: Lessons from GR and PPARs |
| title_full_unstemmed | A Retrospective on Nuclear Receptor Regulation of Inflammation: Lessons from GR and PPARs |
| title_short | A Retrospective on Nuclear Receptor Regulation of Inflammation: Lessons from GR and PPARs |
| title_sort | retrospective on nuclear receptor regulation of inflammation lessons from gr and ppars |
| url | http://dx.doi.org/10.1155/2011/742785 |
| work_keys_str_mv | AT mindianli aretrospectiveonnuclearreceptorregulationofinflammationlessonsfromgrandppars AT xiaoyongyang aretrospectiveonnuclearreceptorregulationofinflammationlessonsfromgrandppars AT mindianli retrospectiveonnuclearreceptorregulationofinflammationlessonsfromgrandppars AT xiaoyongyang retrospectiveonnuclearreceptorregulationofinflammationlessonsfromgrandppars |