Design and synthesis of phenylthiophosphoryl dichloride derivatives and evaluation of their antitumour and anti-inflammatory activities
Tumours and inflammation are serious risks to human health and are importantly regulated by the gas signalling molecule hydrogen sulphide. In this work, we report the rational design and synthesis of H2S donor molecules based on phenylthiophosphoryl dichloride nuclei and assess their efficacy agains...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2024.1529211/full |
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| author | Chunyun Xu Na Yang Haichun Yu Xiaojing Wang |
| author_facet | Chunyun Xu Na Yang Haichun Yu Xiaojing Wang |
| author_sort | Chunyun Xu |
| collection | DOAJ |
| description | Tumours and inflammation are serious risks to human health and are importantly regulated by the gas signalling molecule hydrogen sulphide. In this work, we report the rational design and synthesis of H2S donor molecules based on phenylthiophosphoryl dichloride nuclei and assess their efficacy against tumours and inflammation. We predicted its potential anticancer targets based on network pharmacology and then verified the inhibitory effect of the active compound S11 on the pathway PI3K/AKT by enzyme inhibition and molecular docking assay. In addition, compound S11 exhibited a potent anti-inflammatory effect on macrophages, effectively reducing the levels of inflammatory mediators TNF-α, IL-10 and HO-1. Compound S11 can be used as a new chemical entity for the discovery of new anti-cancer drugs or anti-inflammatory drugs. |
| format | Article |
| id | doaj-art-8e37440fcb9e4c4ba96fa66ee34c7a38 |
| institution | Kabale University |
| issn | 2296-2646 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj-art-8e37440fcb9e4c4ba96fa66ee34c7a382025-01-21T08:36:42ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462025-01-011210.3389/fchem.2024.15292111529211Design and synthesis of phenylthiophosphoryl dichloride derivatives and evaluation of their antitumour and anti-inflammatory activitiesChunyun XuNa YangHaichun YuXiaojing WangTumours and inflammation are serious risks to human health and are importantly regulated by the gas signalling molecule hydrogen sulphide. In this work, we report the rational design and synthesis of H2S donor molecules based on phenylthiophosphoryl dichloride nuclei and assess their efficacy against tumours and inflammation. We predicted its potential anticancer targets based on network pharmacology and then verified the inhibitory effect of the active compound S11 on the pathway PI3K/AKT by enzyme inhibition and molecular docking assay. In addition, compound S11 exhibited a potent anti-inflammatory effect on macrophages, effectively reducing the levels of inflammatory mediators TNF-α, IL-10 and HO-1. Compound S11 can be used as a new chemical entity for the discovery of new anti-cancer drugs or anti-inflammatory drugs.https://www.frontiersin.org/articles/10.3389/fchem.2024.1529211/fullhydrogen sulfidenetwork pharmacologyanti-tumoranti-inflammatoryphenylthiophosphoryl dichloride |
| spellingShingle | Chunyun Xu Na Yang Haichun Yu Xiaojing Wang Design and synthesis of phenylthiophosphoryl dichloride derivatives and evaluation of their antitumour and anti-inflammatory activities Frontiers in Chemistry hydrogen sulfide network pharmacology anti-tumor anti-inflammatory phenylthiophosphoryl dichloride |
| title | Design and synthesis of phenylthiophosphoryl dichloride derivatives and evaluation of their antitumour and anti-inflammatory activities |
| title_full | Design and synthesis of phenylthiophosphoryl dichloride derivatives and evaluation of their antitumour and anti-inflammatory activities |
| title_fullStr | Design and synthesis of phenylthiophosphoryl dichloride derivatives and evaluation of their antitumour and anti-inflammatory activities |
| title_full_unstemmed | Design and synthesis of phenylthiophosphoryl dichloride derivatives and evaluation of their antitumour and anti-inflammatory activities |
| title_short | Design and synthesis of phenylthiophosphoryl dichloride derivatives and evaluation of their antitumour and anti-inflammatory activities |
| title_sort | design and synthesis of phenylthiophosphoryl dichloride derivatives and evaluation of their antitumour and anti inflammatory activities |
| topic | hydrogen sulfide network pharmacology anti-tumor anti-inflammatory phenylthiophosphoryl dichloride |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2024.1529211/full |
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