Evaluation of the Effects of systemic Therapy on Inflammatory Markers and Disease Severity in Patients With Pemphigus
Introduction: In recent years, various inflammatory markers that can change in inflammatory states have been investigated. On the basis of these, we thought that inflammatory markers could also be used in the treatment of pemphigus disease and monitoring its activity. Objective: In this study, ou...
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Mattioli1885
2025-01-01
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| Series: | Dermatology Practical & Conceptual |
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| Online Access: | https://dpcj.org/index.php/dpc/article/view/4969 |
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| author | Mehmet Enes Güner Perihan Ozturk Mine müjde Kuş |
| author_facet | Mehmet Enes Güner Perihan Ozturk Mine müjde Kuş |
| author_sort | Mehmet Enes Güner |
| collection | DOAJ |
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Introduction: In recent years, various inflammatory markers that can change in inflammatory states have been investigated. On the basis of these, we thought that inflammatory markers could also be used in the treatment of pemphigus disease and monitoring its activity.
Objective: In this study, our objective was to investigate changes in the inflammatory markers NLR, PLR, MPV, LMR, CRP and ESR, which are inflammatory markers, before treatment and during follow-up, and the correlation of disease severity with these markers in patients with pemphigus receiving IVIG and/or systemic immunosuppressant agents.
Method: 76 pemphigus patients who received systemic treatment, and used these treatments for at least 6 months were included. Changes in NLR, PLR, LMR, MPV, CRP and sedimentation values were examined in patients who received systemic treatment for at least 6 months, before the start of treatment and 3 and 6 months after the start of treatment.
Results: Significant changes in inflammatory markers and correlation values were found in all patients.
Conclusions: We think that neutrophil, platelet, NLR and PLR values can be used to monitor the response to treatment in pemphigus, since they show a significant decrease with treatment and are significantly positively correlated with PDAI, which indicates the severity of the disease. LMR values were indicators of a poor prognosis. We found that the duration of remission was longer in the group receiving IVIg. Although there was no difference between the treatments in terms of disease recovery, only IVIg prolonged the duration of remission.
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| format | Article |
| id | doaj-art-8e3461fb83c14ed2a7f5e69da9575553 |
| institution | Kabale University |
| issn | 2160-9381 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Mattioli1885 |
| record_format | Article |
| series | Dermatology Practical & Conceptual |
| spelling | doaj-art-8e3461fb83c14ed2a7f5e69da95755532025-02-04T15:41:25ZengMattioli1885Dermatology Practical & Conceptual2160-93812025-01-0115110.5826/dpc.1501a4969Evaluation of the Effects of systemic Therapy on Inflammatory Markers and Disease Severity in Patients With PemphigusMehmet Enes Güner0https://orcid.org/0000-0001-5424-4674Perihan Ozturk1https://orcid.org/0000-0002-9303-6808Mine müjde Kuş2https://orcid.org/0000-0003-3928-7005Kahramanmaras Sutcu Imam University, Kahramanmaras, TurkeyKahramanmaras Sutcu Imam University, Kahramanmaras, TurkeyKahramanmaras Sutcu Imam University, Kahramanmaras, Turkey Introduction: In recent years, various inflammatory markers that can change in inflammatory states have been investigated. On the basis of these, we thought that inflammatory markers could also be used in the treatment of pemphigus disease and monitoring its activity. Objective: In this study, our objective was to investigate changes in the inflammatory markers NLR, PLR, MPV, LMR, CRP and ESR, which are inflammatory markers, before treatment and during follow-up, and the correlation of disease severity with these markers in patients with pemphigus receiving IVIG and/or systemic immunosuppressant agents. Method: 76 pemphigus patients who received systemic treatment, and used these treatments for at least 6 months were included. Changes in NLR, PLR, LMR, MPV, CRP and sedimentation values were examined in patients who received systemic treatment for at least 6 months, before the start of treatment and 3 and 6 months after the start of treatment. Results: Significant changes in inflammatory markers and correlation values were found in all patients. Conclusions: We think that neutrophil, platelet, NLR and PLR values can be used to monitor the response to treatment in pemphigus, since they show a significant decrease with treatment and are significantly positively correlated with PDAI, which indicates the severity of the disease. LMR values were indicators of a poor prognosis. We found that the duration of remission was longer in the group receiving IVIg. Although there was no difference between the treatments in terms of disease recovery, only IVIg prolonged the duration of remission. https://dpcj.org/index.php/dpc/article/view/4969IVIGremissionpemphigusinflammatory markers |
| spellingShingle | Mehmet Enes Güner Perihan Ozturk Mine müjde Kuş Evaluation of the Effects of systemic Therapy on Inflammatory Markers and Disease Severity in Patients With Pemphigus Dermatology Practical & Conceptual IVIG remission pemphigus inflammatory markers |
| title | Evaluation of the Effects of systemic Therapy on Inflammatory Markers and Disease Severity in Patients With Pemphigus |
| title_full | Evaluation of the Effects of systemic Therapy on Inflammatory Markers and Disease Severity in Patients With Pemphigus |
| title_fullStr | Evaluation of the Effects of systemic Therapy on Inflammatory Markers and Disease Severity in Patients With Pemphigus |
| title_full_unstemmed | Evaluation of the Effects of systemic Therapy on Inflammatory Markers and Disease Severity in Patients With Pemphigus |
| title_short | Evaluation of the Effects of systemic Therapy on Inflammatory Markers and Disease Severity in Patients With Pemphigus |
| title_sort | evaluation of the effects of systemic therapy on inflammatory markers and disease severity in patients with pemphigus |
| topic | IVIG remission pemphigus inflammatory markers |
| url | https://dpcj.org/index.php/dpc/article/view/4969 |
| work_keys_str_mv | AT mehmetenesguner evaluationoftheeffectsofsystemictherapyoninflammatorymarkersanddiseaseseverityinpatientswithpemphigus AT perihanozturk evaluationoftheeffectsofsystemictherapyoninflammatorymarkersanddiseaseseverityinpatientswithpemphigus AT minemujdekus evaluationoftheeffectsofsystemictherapyoninflammatorymarkersanddiseaseseverityinpatientswithpemphigus |