Biomarkers in scleroderma: Current status
Scleroderma is an autoimmune disease characterized by indolent obliterative vasculopathy and widespread fibrosis. The two main morphological manifestations of the disease overlap and may make it difficult to separate activity from damage. Many patients, especially those with the limited subset of th...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-01-01
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| Series: | Indian Journal of Rheumatology |
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| Online Access: | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2017;volume=12;issue=6;spage=149;epage=155;aulast=Gupta |
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| _version_ | 1832544070888587264 |
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| author | Latika Gupta Sanat Phatak Sukesh Edavalath |
| author_facet | Latika Gupta Sanat Phatak Sukesh Edavalath |
| author_sort | Latika Gupta |
| collection | DOAJ |
| description | Scleroderma is an autoimmune disease characterized by indolent obliterative vasculopathy and widespread fibrosis. The two main morphological manifestations of the disease overlap and may make it difficult to separate activity from damage. Many patients, especially those with the limited subset of the disease, have an indolent course without clear-cut inflammatory manifestations. There is a felt need for validated biomarkers, which can differentiate activity from damage, and yet be sensitive to change with therapy. Multiplex arrays of biomarkers have ushered an era of targeted or personalized medicine based on phenotypic characteristics in an individual. |
| format | Article |
| id | doaj-art-8e340441eea442ddb813cfa238ca3dd6 |
| institution | Kabale University |
| issn | 0973-3698 0973-3701 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Rheumatology |
| spelling | doaj-art-8e340441eea442ddb813cfa238ca3dd62025-02-03T11:04:40ZengSAGE PublishingIndian Journal of Rheumatology0973-36980973-37012017-01-01126149155Biomarkers in scleroderma: Current statusLatika GuptaSanat PhatakSukesh EdavalathScleroderma is an autoimmune disease characterized by indolent obliterative vasculopathy and widespread fibrosis. The two main morphological manifestations of the disease overlap and may make it difficult to separate activity from damage. Many patients, especially those with the limited subset of the disease, have an indolent course without clear-cut inflammatory manifestations. There is a felt need for validated biomarkers, which can differentiate activity from damage, and yet be sensitive to change with therapy. Multiplex arrays of biomarkers have ushered an era of targeted or personalized medicine based on phenotypic characteristics in an individual.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2017;volume=12;issue=6;spage=149;epage=155;aulast=GuptaBiomarkersfibrosissystemic sclerosis |
| spellingShingle | Latika Gupta Sanat Phatak Sukesh Edavalath Biomarkers in scleroderma: Current status Indian Journal of Rheumatology Biomarkers fibrosis systemic sclerosis |
| title | Biomarkers in scleroderma: Current status |
| title_full | Biomarkers in scleroderma: Current status |
| title_fullStr | Biomarkers in scleroderma: Current status |
| title_full_unstemmed | Biomarkers in scleroderma: Current status |
| title_short | Biomarkers in scleroderma: Current status |
| title_sort | biomarkers in scleroderma current status |
| topic | Biomarkers fibrosis systemic sclerosis |
| url | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2017;volume=12;issue=6;spage=149;epage=155;aulast=Gupta |
| work_keys_str_mv | AT latikagupta biomarkersinsclerodermacurrentstatus AT sanatphatak biomarkersinsclerodermacurrentstatus AT sukeshedavalath biomarkersinsclerodermacurrentstatus |