Dengue virus modulates critical cell cycle regulatory proteins in human megakaryocyte cells

Dengue virus modulates critical cell cycle regulatory proteins in human megakaryocyte cells

Abstract Suppression of human megakaryocytes by dengue virus (DENV) infection significantly reduces the platelet count that eventually leads to thrombocytopenia, severe dengue and death. To understand DENV interactions with megakaryocytes, we investigated the cell cycle in leukemic human megakaryocy...

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Bibliographic Details
Main Authors: Swarnendu Basak, Shovan Dutta, Supreet Khanal, Girish Neelakanta, Hameeda Sultana
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Dengue
Cell cycle
Megakaryocytes
CDK4
CDK1
Cyclin B1
Online Access:https://doi.org/10.1038/s41598-025-02640-5
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