A Case of Philadelphia Chromosome Positive Myeloproliferative Neoplasm in a Pregnant Woman with Unusual Primary Myelofibrosis Features
Myeloproliferative neoplasms (MPNs) are traditionally separated into BCR-ABL-positive chronic myeloid leukemia (CML), and BCR-ABL-negative MPNs including primary myelofibrosis (PMF), essential thrombocythemia (ET), and so forth. One of the diagnostic requirements for PMF and ET is the absence of the...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2013/702831 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551404252692480 |
|---|---|
| author | Jason Koshy Jack Alperin Bagi Jana Avi Markowitz You-Wen Qian |
| author_facet | Jason Koshy Jack Alperin Bagi Jana Avi Markowitz You-Wen Qian |
| author_sort | Jason Koshy |
| collection | DOAJ |
| description | Myeloproliferative neoplasms (MPNs) are traditionally separated into BCR-ABL-positive chronic myeloid leukemia (CML), and BCR-ABL-negative MPNs including primary myelofibrosis (PMF), essential thrombocythemia (ET), and so forth. One of the diagnostic requirements for PMF and ET is the absence of the Philadelphia chromosome, while its presence is almost universally indicative of CML. However, a diagnostic dilemma arises when Philadelphia chromosome-positive MPNs lack the majority of the typical features seen in CML. Some of these classic CML features include basophilIa, marked leukocytosis, neutrophils left-shift with myelocytes bulge, and “dwarf” megakaryocytes. Presented here is a case of a 32-year-old pregnant patient who did not have typical morphologic findings for CML, and yet the Philadelphia chromosome was positive. The patient demonstrated some pathologic features that are commonly presented in PMF that included bone marrow reticulin fibrosis, leukoerythroblastosis, splenomegaly, and increased serum lactate dehydrogenase. |
| format | Article |
| id | doaj-art-8e28ac62562b41bdac3130d8cd425470 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-8e28ac62562b41bdac3130d8cd4254702025-02-03T06:01:29ZengWileyCase Reports in Hematology2090-65602090-65792013-01-01201310.1155/2013/702831702831A Case of Philadelphia Chromosome Positive Myeloproliferative Neoplasm in a Pregnant Woman with Unusual Primary Myelofibrosis FeaturesJason Koshy0Jack Alperin1Bagi Jana2Avi Markowitz3You-Wen Qian4Division of Hematopathology, Department of Pathology and Laboratory Medicine, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USADivision of Hematology and Oncology, Department of Internal Medicine, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USADivision of Hematology and Oncology, Department of Internal Medicine, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USADivision of Hematology and Oncology, Department of Internal Medicine, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USADivision of Hematopathology, Department of Pathology and Laboratory Medicine, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USAMyeloproliferative neoplasms (MPNs) are traditionally separated into BCR-ABL-positive chronic myeloid leukemia (CML), and BCR-ABL-negative MPNs including primary myelofibrosis (PMF), essential thrombocythemia (ET), and so forth. One of the diagnostic requirements for PMF and ET is the absence of the Philadelphia chromosome, while its presence is almost universally indicative of CML. However, a diagnostic dilemma arises when Philadelphia chromosome-positive MPNs lack the majority of the typical features seen in CML. Some of these classic CML features include basophilIa, marked leukocytosis, neutrophils left-shift with myelocytes bulge, and “dwarf” megakaryocytes. Presented here is a case of a 32-year-old pregnant patient who did not have typical morphologic findings for CML, and yet the Philadelphia chromosome was positive. The patient demonstrated some pathologic features that are commonly presented in PMF that included bone marrow reticulin fibrosis, leukoerythroblastosis, splenomegaly, and increased serum lactate dehydrogenase.http://dx.doi.org/10.1155/2013/702831 |
| spellingShingle | Jason Koshy Jack Alperin Bagi Jana Avi Markowitz You-Wen Qian A Case of Philadelphia Chromosome Positive Myeloproliferative Neoplasm in a Pregnant Woman with Unusual Primary Myelofibrosis Features Case Reports in Hematology |
| title | A Case of Philadelphia Chromosome Positive Myeloproliferative Neoplasm in a Pregnant Woman with Unusual Primary Myelofibrosis Features |
| title_full | A Case of Philadelphia Chromosome Positive Myeloproliferative Neoplasm in a Pregnant Woman with Unusual Primary Myelofibrosis Features |
| title_fullStr | A Case of Philadelphia Chromosome Positive Myeloproliferative Neoplasm in a Pregnant Woman with Unusual Primary Myelofibrosis Features |
| title_full_unstemmed | A Case of Philadelphia Chromosome Positive Myeloproliferative Neoplasm in a Pregnant Woman with Unusual Primary Myelofibrosis Features |
| title_short | A Case of Philadelphia Chromosome Positive Myeloproliferative Neoplasm in a Pregnant Woman with Unusual Primary Myelofibrosis Features |
| title_sort | case of philadelphia chromosome positive myeloproliferative neoplasm in a pregnant woman with unusual primary myelofibrosis features |
| url | http://dx.doi.org/10.1155/2013/702831 |
| work_keys_str_mv | AT jasonkoshy acaseofphiladelphiachromosomepositivemyeloproliferativeneoplasminapregnantwomanwithunusualprimarymyelofibrosisfeatures AT jackalperin acaseofphiladelphiachromosomepositivemyeloproliferativeneoplasminapregnantwomanwithunusualprimarymyelofibrosisfeatures AT bagijana acaseofphiladelphiachromosomepositivemyeloproliferativeneoplasminapregnantwomanwithunusualprimarymyelofibrosisfeatures AT avimarkowitz acaseofphiladelphiachromosomepositivemyeloproliferativeneoplasminapregnantwomanwithunusualprimarymyelofibrosisfeatures AT youwenqian acaseofphiladelphiachromosomepositivemyeloproliferativeneoplasminapregnantwomanwithunusualprimarymyelofibrosisfeatures AT jasonkoshy caseofphiladelphiachromosomepositivemyeloproliferativeneoplasminapregnantwomanwithunusualprimarymyelofibrosisfeatures AT jackalperin caseofphiladelphiachromosomepositivemyeloproliferativeneoplasminapregnantwomanwithunusualprimarymyelofibrosisfeatures AT bagijana caseofphiladelphiachromosomepositivemyeloproliferativeneoplasminapregnantwomanwithunusualprimarymyelofibrosisfeatures AT avimarkowitz caseofphiladelphiachromosomepositivemyeloproliferativeneoplasminapregnantwomanwithunusualprimarymyelofibrosisfeatures AT youwenqian caseofphiladelphiachromosomepositivemyeloproliferativeneoplasminapregnantwomanwithunusualprimarymyelofibrosisfeatures |