Development of RT-PCR Assays for Simple Detection and Identification of Sabin Virus Contaminants in the Novel Oral Poliovirus Vaccines

Development of RT-PCR Assays for Simple Detection and Identification of Sabin Virus Contaminants in the Novel Oral Poliovirus Vaccines

Background/Objectives: Conventional live oral poliovirus vaccines (OPVs) effectively prevent poliomyelitis. These vaccines are derived from three attenuated Sabin strains of poliovirus, which can revert within the first week of replication to a neurovirulent phenotype, leading to sporadic cases of v...

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Bibliographic Details
Main Authors: Olga Singh, Hasmik Manukyan, Erman Tritama, Shwu-Maan Lee, Jerry P. Weir, Majid Laassri
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Vaccines
Subjects:
viral contamination
OPV
nOPV
RT-PCR
vaccines
poliovirus
Online Access:https://www.mdpi.com/2076-393X/13/1/75
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