Follicular Regulatory T Cells in Systemic Lupus Erythematosus
Follicular regulatory T (Tfr) cells are the regulatory T cell subset mainly localized in the germinal center (GC), acting as modulators of GC responses. They can disrupt Tfh cell- and B cell-linked recognition, induce Tfh apoptosis, and suppress B cell function. Evidences show that dysregulated Tfr...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/9943743 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832561159164657664 |
|---|---|
| author | Xin Xia Jun Yang Shengjun Wang |
| author_facet | Xin Xia Jun Yang Shengjun Wang |
| author_sort | Xin Xia |
| collection | DOAJ |
| description | Follicular regulatory T (Tfr) cells are the regulatory T cell subset mainly localized in the germinal center (GC), acting as modulators of GC responses. They can disrupt Tfh cell- and B cell-linked recognition, induce Tfh apoptosis, and suppress B cell function. Evidences show that dysregulated Tfr cells are associated with the disease activity index and serum autoantibody levels, influencing the development of systemic lupus erythematosus (SLE). This review focuses on the interaction among Tfr, Tfh, and B cells, summarizes the characterization and function of Tfr cells, concludes the imbalance of CD4+T subsets in SLE, and presents potential therapies for SLE. In general, we discuss the roles of Tfr cells in the progress of SLE and provide potential treatments. |
| format | Article |
| id | doaj-art-8e103d1fb5cd4fda969e98461556c365 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-8e103d1fb5cd4fda969e98461556c3652025-02-03T01:25:49ZengWileyJournal of Immunology Research2314-88612314-71562021-01-01202110.1155/2021/99437439943743Follicular Regulatory T Cells in Systemic Lupus ErythematosusXin Xia0Jun Yang1Shengjun Wang2Department of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang, ChinaDepartment of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang, ChinaDepartment of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang, ChinaFollicular regulatory T (Tfr) cells are the regulatory T cell subset mainly localized in the germinal center (GC), acting as modulators of GC responses. They can disrupt Tfh cell- and B cell-linked recognition, induce Tfh apoptosis, and suppress B cell function. Evidences show that dysregulated Tfr cells are associated with the disease activity index and serum autoantibody levels, influencing the development of systemic lupus erythematosus (SLE). This review focuses on the interaction among Tfr, Tfh, and B cells, summarizes the characterization and function of Tfr cells, concludes the imbalance of CD4+T subsets in SLE, and presents potential therapies for SLE. In general, we discuss the roles of Tfr cells in the progress of SLE and provide potential treatments.http://dx.doi.org/10.1155/2021/9943743 |
| spellingShingle | Xin Xia Jun Yang Shengjun Wang Follicular Regulatory T Cells in Systemic Lupus Erythematosus Journal of Immunology Research |
| title | Follicular Regulatory T Cells in Systemic Lupus Erythematosus |
| title_full | Follicular Regulatory T Cells in Systemic Lupus Erythematosus |
| title_fullStr | Follicular Regulatory T Cells in Systemic Lupus Erythematosus |
| title_full_unstemmed | Follicular Regulatory T Cells in Systemic Lupus Erythematosus |
| title_short | Follicular Regulatory T Cells in Systemic Lupus Erythematosus |
| title_sort | follicular regulatory t cells in systemic lupus erythematosus |
| url | http://dx.doi.org/10.1155/2021/9943743 |
| work_keys_str_mv | AT xinxia follicularregulatorytcellsinsystemiclupuserythematosus AT junyang follicularregulatorytcellsinsystemiclupuserythematosus AT shengjunwang follicularregulatorytcellsinsystemiclupuserythematosus |