Ultrafine Resveratrol Particles: Supercritical Antisolvent Preparation and Evaluation In Vitro and In Vivo
Ultrafine resveratrol (u-Res) particles were prepared through the SAS process. The orthogonal method was used to optimize the factors of the SAS process. The size of u-Res reached 0.68 μm under the optimum conditions. The characterization of the u-Res particles was tested by many analysis methods. T...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Advances in Materials Science and Engineering |
| Online Access: | http://dx.doi.org/10.1155/2015/838513 |
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| author | Kunlun Wang Xiuhua Zhao Yuangang Zu Jialei Li Xiaonan Zhang Wei Sun Xinyang Yu |
| author_facet | Kunlun Wang Xiuhua Zhao Yuangang Zu Jialei Li Xiaonan Zhang Wei Sun Xinyang Yu |
| author_sort | Kunlun Wang |
| collection | DOAJ |
| description | Ultrafine resveratrol (u-Res) particles were prepared through the SAS process. The orthogonal method was used to optimize the factors of the SAS process. The size of u-Res reached 0.68 μm under the optimum conditions. The characterization of the u-Res particles was tested by many analysis methods. The chemical structure of Res was unaffected by the SAS process. The degree of crystallinity of the u-Res particles greatly reduced. The purity of the u-Res particles increased from 98.5% to 99.2% during the SAS process. The u-Res particles had greater saturation solubility and dissolution rate than the raw-Res (r-Res) particles. The radical scavenging activity and bioavailability of the u-Res in vivo were 1.9 times of the r-Res. |
| format | Article |
| id | doaj-art-8e04bca45826410bae002b66c8e8d8a5 |
| institution | Kabale University |
| issn | 1687-8434 1687-8442 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Materials Science and Engineering |
| spelling | doaj-art-8e04bca45826410bae002b66c8e8d8a52025-02-03T00:59:07ZengWileyAdvances in Materials Science and Engineering1687-84341687-84422015-01-01201510.1155/2015/838513838513Ultrafine Resveratrol Particles: Supercritical Antisolvent Preparation and Evaluation In Vitro and In VivoKunlun Wang0Xiuhua Zhao1Yuangang Zu2Jialei Li3Xiaonan Zhang4Wei Sun5Xinyang Yu6Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Hexing Road 26, Heilongjiang, Harbin 150040, ChinaKey Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Hexing Road 26, Heilongjiang, Harbin 150040, ChinaKey Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Hexing Road 26, Heilongjiang, Harbin 150040, ChinaKey Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Hexing Road 26, Heilongjiang, Harbin 150040, ChinaKey Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Hexing Road 26, Heilongjiang, Harbin 150040, ChinaKey Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Hexing Road 26, Heilongjiang, Harbin 150040, ChinaKey Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Hexing Road 26, Heilongjiang, Harbin 150040, ChinaUltrafine resveratrol (u-Res) particles were prepared through the SAS process. The orthogonal method was used to optimize the factors of the SAS process. The size of u-Res reached 0.68 μm under the optimum conditions. The characterization of the u-Res particles was tested by many analysis methods. The chemical structure of Res was unaffected by the SAS process. The degree of crystallinity of the u-Res particles greatly reduced. The purity of the u-Res particles increased from 98.5% to 99.2% during the SAS process. The u-Res particles had greater saturation solubility and dissolution rate than the raw-Res (r-Res) particles. The radical scavenging activity and bioavailability of the u-Res in vivo were 1.9 times of the r-Res.http://dx.doi.org/10.1155/2015/838513 |
| spellingShingle | Kunlun Wang Xiuhua Zhao Yuangang Zu Jialei Li Xiaonan Zhang Wei Sun Xinyang Yu Ultrafine Resveratrol Particles: Supercritical Antisolvent Preparation and Evaluation In Vitro and In Vivo Advances in Materials Science and Engineering |
| title | Ultrafine Resveratrol Particles: Supercritical Antisolvent Preparation and Evaluation In Vitro and In Vivo |
| title_full | Ultrafine Resveratrol Particles: Supercritical Antisolvent Preparation and Evaluation In Vitro and In Vivo |
| title_fullStr | Ultrafine Resveratrol Particles: Supercritical Antisolvent Preparation and Evaluation In Vitro and In Vivo |
| title_full_unstemmed | Ultrafine Resveratrol Particles: Supercritical Antisolvent Preparation and Evaluation In Vitro and In Vivo |
| title_short | Ultrafine Resveratrol Particles: Supercritical Antisolvent Preparation and Evaluation In Vitro and In Vivo |
| title_sort | ultrafine resveratrol particles supercritical antisolvent preparation and evaluation in vitro and in vivo |
| url | http://dx.doi.org/10.1155/2015/838513 |
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