A Recent Overview of 1,2,3-Triazole-Containing Hybrids as Novel Antifungal Agents: Focusing on Synthesis, Mechanism of Action, and Structure-Activity Relationship (SAR)
A pharmacophore system has been found as 1,2,3-triazole, a five-membered heterocycle ring with nitrogen heteroatoms. These heterocyclic compounds can be produced using azide-alkyne cycloaddition processes catalyzed by ruthenium or copper. The bioactive compounds demonstrated antitubercular, antibact...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2022/7884316 |
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| author | Mahrokh Marzi Mojtaba Farjam Zahra Kazeminejad Abolfazl Shiroudi Amin Kouhpayeh Elham Zarenezhad |
| author_facet | Mahrokh Marzi Mojtaba Farjam Zahra Kazeminejad Abolfazl Shiroudi Amin Kouhpayeh Elham Zarenezhad |
| author_sort | Mahrokh Marzi |
| collection | DOAJ |
| description | A pharmacophore system has been found as 1,2,3-triazole, a five-membered heterocycle ring with nitrogen heteroatoms. These heterocyclic compounds can be produced using azide-alkyne cycloaddition processes catalyzed by ruthenium or copper. The bioactive compounds demonstrated antitubercular, antibacterial, anti-inflammatory, anticancer, antioxidant, antiviral, and antidiabetic properties. This heterocycle molecule, in particular, with one or more 1,2,3-triazole cores has been found to have the most powerful antifungal effects. The goal of this review is to highlight recent developments in the synthesis and structure-activity relationship (SAR) investigation of this prospective fungicidal chemical. Also there have been explained drugs and mechanism of action of a triazole compound with antifungal activity. This review will be useful in a variety of fields, including medicinal chemistry, organic chemistry, mycology, and pharmacology. |
| format | Article |
| id | doaj-art-8dfcdeb6bee6467ca522a88b3ce9f1e6 |
| institution | Kabale University |
| issn | 2090-9071 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-8dfcdeb6bee6467ca522a88b3ce9f1e62025-02-03T05:54:30ZengWileyJournal of Chemistry2090-90712022-01-01202210.1155/2022/7884316A Recent Overview of 1,2,3-Triazole-Containing Hybrids as Novel Antifungal Agents: Focusing on Synthesis, Mechanism of Action, and Structure-Activity Relationship (SAR)Mahrokh Marzi0Mojtaba Farjam1Zahra Kazeminejad2Abolfazl Shiroudi3Amin Kouhpayeh4Elham Zarenezhad5Noncommunicable Diseases Research CenterNoncommunicable Diseases Research CenterYoung Researchers and Elite ClubYoung Researchers and Elite ClubDepartment of Medical PharmacologyNoncommunicable Diseases Research CenterA pharmacophore system has been found as 1,2,3-triazole, a five-membered heterocycle ring with nitrogen heteroatoms. These heterocyclic compounds can be produced using azide-alkyne cycloaddition processes catalyzed by ruthenium or copper. The bioactive compounds demonstrated antitubercular, antibacterial, anti-inflammatory, anticancer, antioxidant, antiviral, and antidiabetic properties. This heterocycle molecule, in particular, with one or more 1,2,3-triazole cores has been found to have the most powerful antifungal effects. The goal of this review is to highlight recent developments in the synthesis and structure-activity relationship (SAR) investigation of this prospective fungicidal chemical. Also there have been explained drugs and mechanism of action of a triazole compound with antifungal activity. This review will be useful in a variety of fields, including medicinal chemistry, organic chemistry, mycology, and pharmacology.http://dx.doi.org/10.1155/2022/7884316 |
| spellingShingle | Mahrokh Marzi Mojtaba Farjam Zahra Kazeminejad Abolfazl Shiroudi Amin Kouhpayeh Elham Zarenezhad A Recent Overview of 1,2,3-Triazole-Containing Hybrids as Novel Antifungal Agents: Focusing on Synthesis, Mechanism of Action, and Structure-Activity Relationship (SAR) Journal of Chemistry |
| title | A Recent Overview of 1,2,3-Triazole-Containing Hybrids as Novel Antifungal Agents: Focusing on Synthesis, Mechanism of Action, and Structure-Activity Relationship (SAR) |
| title_full | A Recent Overview of 1,2,3-Triazole-Containing Hybrids as Novel Antifungal Agents: Focusing on Synthesis, Mechanism of Action, and Structure-Activity Relationship (SAR) |
| title_fullStr | A Recent Overview of 1,2,3-Triazole-Containing Hybrids as Novel Antifungal Agents: Focusing on Synthesis, Mechanism of Action, and Structure-Activity Relationship (SAR) |
| title_full_unstemmed | A Recent Overview of 1,2,3-Triazole-Containing Hybrids as Novel Antifungal Agents: Focusing on Synthesis, Mechanism of Action, and Structure-Activity Relationship (SAR) |
| title_short | A Recent Overview of 1,2,3-Triazole-Containing Hybrids as Novel Antifungal Agents: Focusing on Synthesis, Mechanism of Action, and Structure-Activity Relationship (SAR) |
| title_sort | recent overview of 1 2 3 triazole containing hybrids as novel antifungal agents focusing on synthesis mechanism of action and structure activity relationship sar |
| url | http://dx.doi.org/10.1155/2022/7884316 |
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