Pharmacological analysis of the role of kisspeptin-10 in reinforcing mechanisms
Introduction: Behavioral and substance addictions are driven by shared neurobiological mechanisms, often involving the reward system. Kisspeptin-10, a neuropeptide primarily linked to reproductive functions, has emerged as a potential modulator of reward-related behaviors and decision-making. This s...
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| Language: | English |
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Belgorod National Research University
2025-03-01
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| Series: | Research Results in Pharmacology |
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| Online Access: | https://rrpharmacology.ru/index.php/journal/article/view/544 |
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| author | Sarng S. Pyurveev Andrei A. Lebedev Eugeny R. Bychkov Petr D. Shabanov |
| author_facet | Sarng S. Pyurveev Andrei A. Lebedev Eugeny R. Bychkov Petr D. Shabanov |
| author_sort | Sarng S. Pyurveev |
| collection | DOAJ |
| description | Introduction: Behavioral and substance addictions are driven by shared neurobiological mechanisms, often involving the reward system. Kisspeptin-10, a neuropeptide primarily linked to reproductive functions, has emerged as a potential modulator of reward-related behaviors and decision-making. This study explores the effects of kisspeptin-10 on impulsivity, compulsivity, and reinforcement mechanisms.
Materials and Methods: Male Wistar rats were used to assess the effects of kisspeptin-10 on behavior. A conditioned place preference (CPP) test evaluated reinforcement effects at doses of 0.1 mg/kg, 0.5 mg/kg, and 1 mg/kg. A modified Iowa Gambling Task analyzed decision-making and impulsivity under variable reinforcement schedules. The marble-burying test was employed to assess compulsive behaviors. Statistical analysis included one-way ANOVA and Tukey's post-hoc test.
Results and Discussion: Kisspeptin-10 at 1 mg/kg induced a significant CPP response, suggesting reinforcing properties. In the gambling task, kisspeptin-10 enhanced impulsive choices by increasing preference for riskier reinforcement schedules, contrasting with the stabilizing effects of paroxetine. In the marble-burying test, kisspeptin-10 increased compulsive behavior compared to paroxetine, underscoring its modulatory role in compulsivity. These effects likely reflect kisspeptin-10’s interaction with dopaminergic and serotonergic systems, extending its influence beyond reproductive functions.
Conclusion: Kisspeptin-10 dose 1 mg/kg significantly modulates impulsive and compulsive behaviors, as well as reinforcing mechanisms, highlighting its potential as a therapeutic target for conditions characterized by dysregulated decision-making and compulsivity. |
| format | Article |
| id | doaj-art-8df6e43f2f4241f9ab6f773fa3b54cad |
| institution | DOAJ |
| issn | 2658-381X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Belgorod National Research University |
| record_format | Article |
| series | Research Results in Pharmacology |
| spelling | doaj-art-8df6e43f2f4241f9ab6f773fa3b54cad2025-08-20T03:08:22ZengBelgorod National Research UniversityResearch Results in Pharmacology2658-381X2025-03-01111586810.18413/rrpharmacology.11.544Pharmacological analysis of the role of kisspeptin-10 in reinforcing mechanismsSarng S. Pyurveev0https://orcid.org/0000-0002-4467-2269Andrei A. Lebedev1https://orcid.org/0000-0003-0297-0425Eugeny R. Bychkov2https://orcid.org/0000-0003-1068-4701Petr D. Shabanov3https://orcid.org/0000-0003-1464-1127Institute of Experimental Medicine; St. Petersburg State Medical Pediatric UniversityInstitute of Experimental MedicineInstitute of Experimental MedicineInstitute of Experimental MedicineIntroduction: Behavioral and substance addictions are driven by shared neurobiological mechanisms, often involving the reward system. Kisspeptin-10, a neuropeptide primarily linked to reproductive functions, has emerged as a potential modulator of reward-related behaviors and decision-making. This study explores the effects of kisspeptin-10 on impulsivity, compulsivity, and reinforcement mechanisms. Materials and Methods: Male Wistar rats were used to assess the effects of kisspeptin-10 on behavior. A conditioned place preference (CPP) test evaluated reinforcement effects at doses of 0.1 mg/kg, 0.5 mg/kg, and 1 mg/kg. A modified Iowa Gambling Task analyzed decision-making and impulsivity under variable reinforcement schedules. The marble-burying test was employed to assess compulsive behaviors. Statistical analysis included one-way ANOVA and Tukey's post-hoc test. Results and Discussion: Kisspeptin-10 at 1 mg/kg induced a significant CPP response, suggesting reinforcing properties. In the gambling task, kisspeptin-10 enhanced impulsive choices by increasing preference for riskier reinforcement schedules, contrasting with the stabilizing effects of paroxetine. In the marble-burying test, kisspeptin-10 increased compulsive behavior compared to paroxetine, underscoring its modulatory role in compulsivity. These effects likely reflect kisspeptin-10’s interaction with dopaminergic and serotonergic systems, extending its influence beyond reproductive functions. Conclusion: Kisspeptin-10 dose 1 mg/kg significantly modulates impulsive and compulsive behaviors, as well as reinforcing mechanisms, highlighting its potential as a therapeutic target for conditions characterized by dysregulated decision-making and compulsivity.https://rrpharmacology.ru/index.php/journal/article/view/544kisspeptin-10impulsivitycompulsivityreinforcementconditioned place preferencebehavioral addiction |
| spellingShingle | Sarng S. Pyurveev Andrei A. Lebedev Eugeny R. Bychkov Petr D. Shabanov Pharmacological analysis of the role of kisspeptin-10 in reinforcing mechanisms Research Results in Pharmacology kisspeptin-10 impulsivity compulsivity reinforcement conditioned place preference behavioral addiction |
| title | Pharmacological analysis of the role of kisspeptin-10 in reinforcing mechanisms |
| title_full | Pharmacological analysis of the role of kisspeptin-10 in reinforcing mechanisms |
| title_fullStr | Pharmacological analysis of the role of kisspeptin-10 in reinforcing mechanisms |
| title_full_unstemmed | Pharmacological analysis of the role of kisspeptin-10 in reinforcing mechanisms |
| title_short | Pharmacological analysis of the role of kisspeptin-10 in reinforcing mechanisms |
| title_sort | pharmacological analysis of the role of kisspeptin 10 in reinforcing mechanisms |
| topic | kisspeptin-10 impulsivity compulsivity reinforcement conditioned place preference behavioral addiction |
| url | https://rrpharmacology.ru/index.php/journal/article/view/544 |
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