METTL14 modulates the progression and ferroptosis of colitis by regulating the stability of m6A-modified GPX4

METTL14 modulates the progression and ferroptosis of colitis by regulating the stability of m6A-modified GPX4

Abstract Ulcerative colitis (UC) is non-specific inflammatory bowel disease. UC development and progression were closely associated with epigenetic modifications. Nevertheless, the specific relationship between N6-methyladenosine (m6A) modification at RNA transcription levels and UC pathogenesis rem...

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Bibliographic Details
Main Authors: Yuhua Chen, Weicong Fan, Ying Lyu, Jingsheng Liao, Ying Zhou
Format: Article
Language:English
Published: BMC 2025-02-01
Series:European Journal of Medical Research
Subjects:
Colitis
METTL14
m6A
GPX4
Ferroptosis
Online Access:https://doi.org/10.1186/s40001-025-02334-8
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