Potentiation of Antidepressant Effects of Agomelatine and Bupropion by Hesperidin in Mice

Hesperidin, a well-known flavanone glycoside mostly found in citrus fruits, showed neuroprotective and antidepressant activity. Agomelatine, a melatonergic MT1/MT2 agonist and 5-HT2C receptor antagonist, exhibits good antidepressant efficacy. Bupropion has been widely used for the treatment of depre...

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Bibliographic Details
Main Authors: Jegan Sakthivel Nadar, Pravin Popatrao Kale, Pramod Kerunath Kadu, Kedar Prabhavalkar, Ruchita Dhangar
Format: Article
Language:English
Published: Wiley 2018-01-01
Series:Neurology Research International
Online Access:http://dx.doi.org/10.1155/2018/9828639
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