Potentiation of Antidepressant Effects of Agomelatine and Bupropion by Hesperidin in Mice
Hesperidin, a well-known flavanone glycoside mostly found in citrus fruits, showed neuroprotective and antidepressant activity. Agomelatine, a melatonergic MT1/MT2 agonist and 5-HT2C receptor antagonist, exhibits good antidepressant efficacy. Bupropion has been widely used for the treatment of depre...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2018/9828639 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832552028822306816 |
|---|---|
| author | Jegan Sakthivel Nadar Pravin Popatrao Kale Pramod Kerunath Kadu Kedar Prabhavalkar Ruchita Dhangar |
| author_facet | Jegan Sakthivel Nadar Pravin Popatrao Kale Pramod Kerunath Kadu Kedar Prabhavalkar Ruchita Dhangar |
| author_sort | Jegan Sakthivel Nadar |
| collection | DOAJ |
| description | Hesperidin, a well-known flavanone glycoside mostly found in citrus fruits, showed neuroprotective and antidepressant activity. Agomelatine, a melatonergic MT1/MT2 agonist and 5-HT2C receptor antagonist, exhibits good antidepressant efficacy. Bupropion has been widely used for the treatment of depression because of its dopamine and norepinephrine reuptake inhibition. The objective of present study was to assess the antidepressant effects of hesperidin combination with agomelatine or bupropion. Male Swiss Albino mice received treatment of saline, vehicle, ‘hesperidin alone’, ‘agomelatine alone’, hesperidin+agomelatine, ‘bupropion alone’, hesperidin+bupropion, and agomelatine+bupropion for 14 days. The immobility period was analysed 30 min after the treatment in forced swim and tail suspension tests. Dopamine and serotonin levels were analysed in hippocampus, cerebral cortex, and whole brain using HPLC with fluorescence detector. Hesperidin plus agomelatine treated group was better in terms of decrease in immobility period and increase in dopamine and serotonin levels when compared to their respective monotherapy treated groups. |
| format | Article |
| id | doaj-art-8dda391e11d44715b171af0c4c21f68b |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-8dda391e11d44715b171af0c4c21f68b2025-02-03T05:59:51ZengWileyNeurology Research International2090-18522090-18602018-01-01201810.1155/2018/98286399828639Potentiation of Antidepressant Effects of Agomelatine and Bupropion by Hesperidin in MiceJegan Sakthivel Nadar0Pravin Popatrao Kale1Pramod Kerunath Kadu2Kedar Prabhavalkar3Ruchita Dhangar4Department of Pharmacology, SVKM’S Dr. Bhanuben Nanavati College of Pharmacy, V. M. Road, Mithibai Campus, Vile Parle West, Mumbai 400 056, IndiaDepartment of Pharmacology, SVKM’S Dr. Bhanuben Nanavati College of Pharmacy, V. M. Road, Mithibai Campus, Vile Parle West, Mumbai 400 056, IndiaDepartment of Pharmaceutics, SVKM’S Dr. Bhanuben Nanavati College of Pharmacy, V. M. Road, Mithibai Campus, Vile Parle West, Mumbai 400 056, IndiaDepartment of Pharmacology, SVKM’S Dr. Bhanuben Nanavati College of Pharmacy, V. M. Road, Mithibai Campus, Vile Parle West, Mumbai 400 056, IndiaDepartment of Pharmacology, SVKM’S Dr. Bhanuben Nanavati College of Pharmacy, V. M. Road, Mithibai Campus, Vile Parle West, Mumbai 400 056, IndiaHesperidin, a well-known flavanone glycoside mostly found in citrus fruits, showed neuroprotective and antidepressant activity. Agomelatine, a melatonergic MT1/MT2 agonist and 5-HT2C receptor antagonist, exhibits good antidepressant efficacy. Bupropion has been widely used for the treatment of depression because of its dopamine and norepinephrine reuptake inhibition. The objective of present study was to assess the antidepressant effects of hesperidin combination with agomelatine or bupropion. Male Swiss Albino mice received treatment of saline, vehicle, ‘hesperidin alone’, ‘agomelatine alone’, hesperidin+agomelatine, ‘bupropion alone’, hesperidin+bupropion, and agomelatine+bupropion for 14 days. The immobility period was analysed 30 min after the treatment in forced swim and tail suspension tests. Dopamine and serotonin levels were analysed in hippocampus, cerebral cortex, and whole brain using HPLC with fluorescence detector. Hesperidin plus agomelatine treated group was better in terms of decrease in immobility period and increase in dopamine and serotonin levels when compared to their respective monotherapy treated groups.http://dx.doi.org/10.1155/2018/9828639 |
| spellingShingle | Jegan Sakthivel Nadar Pravin Popatrao Kale Pramod Kerunath Kadu Kedar Prabhavalkar Ruchita Dhangar Potentiation of Antidepressant Effects of Agomelatine and Bupropion by Hesperidin in Mice Neurology Research International |
| title | Potentiation of Antidepressant Effects of Agomelatine and Bupropion by Hesperidin in Mice |
| title_full | Potentiation of Antidepressant Effects of Agomelatine and Bupropion by Hesperidin in Mice |
| title_fullStr | Potentiation of Antidepressant Effects of Agomelatine and Bupropion by Hesperidin in Mice |
| title_full_unstemmed | Potentiation of Antidepressant Effects of Agomelatine and Bupropion by Hesperidin in Mice |
| title_short | Potentiation of Antidepressant Effects of Agomelatine and Bupropion by Hesperidin in Mice |
| title_sort | potentiation of antidepressant effects of agomelatine and bupropion by hesperidin in mice |
| url | http://dx.doi.org/10.1155/2018/9828639 |
| work_keys_str_mv | AT jegansakthivelnadar potentiationofantidepressanteffectsofagomelatineandbupropionbyhesperidininmice AT pravinpopatraokale potentiationofantidepressanteffectsofagomelatineandbupropionbyhesperidininmice AT pramodkerunathkadu potentiationofantidepressanteffectsofagomelatineandbupropionbyhesperidininmice AT kedarprabhavalkar potentiationofantidepressanteffectsofagomelatineandbupropionbyhesperidininmice AT ruchitadhangar potentiationofantidepressanteffectsofagomelatineandbupropionbyhesperidininmice |