Development of Agranulocytosis after Discontinuation of Methimazole: An Unusual Case
Agranulocytosis is a rare and critical adverse effect of antithyroid drugs (ATD). The occurrence of agranulocytosis in continuous ATD treatment patients is well known; however, a case of ATD agranulocytosis occurring following the discontinuation of methimazole (MMI) treatment is not a usual situati...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/974524 |
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| author | Rıfkı Üçler Murat Atmaca Ömer Candar Murat Alay Burhan Göy Erdal Kara Mahfuz Turan Yusuf Demir |
| author_facet | Rıfkı Üçler Murat Atmaca Ömer Candar Murat Alay Burhan Göy Erdal Kara Mahfuz Turan Yusuf Demir |
| author_sort | Rıfkı Üçler |
| collection | DOAJ |
| description | Agranulocytosis is a rare and critical adverse effect of antithyroid drugs (ATD). The occurrence of agranulocytosis in continuous ATD treatment patients is well known; however, a case of ATD agranulocytosis occurring following the discontinuation of methimazole (MMI) treatment is not a usual situation. We herein describe a case of a 41-year-old woman who was previously administered methimazole (MMI) for ten days and developed ATD-induced agranulocytosis and symptoms of an upper respiratory tract infection after three weeks following discontinuation of MMI treatment. A thorough hematologic and serological evaluation did not disclose an alternative cause for the agranulocytosis. After receiving empirical antibiotic treatment, she responded successfully with clinical improvement of her symptoms and resolved neutropenia on the seventh day. This case is atypical because agranulocytosis developed after discontinuation of MMI, which strengthens the importance of remaining alert for signs of agranulocytosis even after discontinuation of ATD treatment. |
| format | Article |
| id | doaj-art-8dd82f1117c14959836980f26dd971cb |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-8dd82f1117c14959836980f26dd971cb2025-02-03T01:22:47ZengWileyCase Reports in Endocrinology2090-65012090-651X2015-01-01201510.1155/2015/974524974524Development of Agranulocytosis after Discontinuation of Methimazole: An Unusual CaseRıfkı Üçler0Murat Atmaca1Ömer Candar2Murat Alay3Burhan Göy4Erdal Kara5Mahfuz Turan6Yusuf Demir7Department of Endocrinology and Metabolism, Yuzuncu Yil University Faculty of Medicine, 65080 Van, TurkeyDepartment of Endocrinology and Metabolism, Yuzuncu Yil University Faculty of Medicine, 65080 Van, TurkeyDepartment of Internal Medicine, Yuzuncu Yil University Faculty of Medicine, 65080 Van, TurkeyDepartment of Endocrinology and Metabolism, Yuzuncu Yil University Faculty of Medicine, 65080 Van, TurkeyDepartment of Internal Medicine, Bulanık State Hospital, 49500 Mus, TurkeyDepartment of Hematology, Yuzuncu Yil University Faculty of Medicine, 65080 Van, TurkeyDepartment of Otorhinolaryngology, Yuzuncu Yil University Faculty of Medicine, 65080 Van, TurkeyDepartment of Nuclear Medicine, Yuzuncu Yil University Faculty of Medicine, 65080 Van, TurkeyAgranulocytosis is a rare and critical adverse effect of antithyroid drugs (ATD). The occurrence of agranulocytosis in continuous ATD treatment patients is well known; however, a case of ATD agranulocytosis occurring following the discontinuation of methimazole (MMI) treatment is not a usual situation. We herein describe a case of a 41-year-old woman who was previously administered methimazole (MMI) for ten days and developed ATD-induced agranulocytosis and symptoms of an upper respiratory tract infection after three weeks following discontinuation of MMI treatment. A thorough hematologic and serological evaluation did not disclose an alternative cause for the agranulocytosis. After receiving empirical antibiotic treatment, she responded successfully with clinical improvement of her symptoms and resolved neutropenia on the seventh day. This case is atypical because agranulocytosis developed after discontinuation of MMI, which strengthens the importance of remaining alert for signs of agranulocytosis even after discontinuation of ATD treatment.http://dx.doi.org/10.1155/2015/974524 |
| spellingShingle | Rıfkı Üçler Murat Atmaca Ömer Candar Murat Alay Burhan Göy Erdal Kara Mahfuz Turan Yusuf Demir Development of Agranulocytosis after Discontinuation of Methimazole: An Unusual Case Case Reports in Endocrinology |
| title | Development of Agranulocytosis after Discontinuation of Methimazole: An Unusual Case |
| title_full | Development of Agranulocytosis after Discontinuation of Methimazole: An Unusual Case |
| title_fullStr | Development of Agranulocytosis after Discontinuation of Methimazole: An Unusual Case |
| title_full_unstemmed | Development of Agranulocytosis after Discontinuation of Methimazole: An Unusual Case |
| title_short | Development of Agranulocytosis after Discontinuation of Methimazole: An Unusual Case |
| title_sort | development of agranulocytosis after discontinuation of methimazole an unusual case |
| url | http://dx.doi.org/10.1155/2015/974524 |
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