The clinical value of systemic immune-inflammation index (SII) and prognostic nutritional index (PNI) for predicting the occurrence of metastasis in patients with lung cancer
Systemic immune-inflammation index (SII) and prognostic nutritional index (PNI) serve as simple and practical tests that help indicate inflammatory and nutritional status to some extent. Lung cancer stands out as the most common contributor to cancer-related mortality globally. It is associated wit...
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Universitas Nahdlatul Ulama Surabaya
2025-04-01
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| Series: | Indonesian Journal of Medical Laboratory Science and Technology |
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| Online Access: | http://journal2.unusa.ac.id/index.php/IJMLST/article/view/5628 |
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| author | Verna Biutifasari Ellen Angelique Hardjono Ronald Pratama Adiwinoto Janto Poernomo Hadi |
| author_facet | Verna Biutifasari Ellen Angelique Hardjono Ronald Pratama Adiwinoto Janto Poernomo Hadi |
| author_sort | Verna Biutifasari |
| collection | DOAJ |
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Systemic immune-inflammation index (SII) and prognostic nutritional index (PNI) serve as simple and practical tests that help indicate inflammatory and nutritional status to some extent. Lung cancer stands out as the most common contributor to cancer-related mortality globally. It is associated with an unfavorable prognosis. Most patients diagnosed with lung cancer have metastasis at the time of diagnosis. Prognostic heterogeneity of cancer patients causes the need for more prognostic biomarkers. This study aimed to evaluate the clinical value of SII and PNI in predicting metastasis in lung cancer patients. SII and PNI provides a prognostic value in lung cancer. Retrospective cross-sectional research was conducted in this study involving 138 data from medical records at the Inpatient and Outpatient Department of Pulmonology, RSPAL dr. Ramelan Surabaya in April 2019 to July 2023. Kolmogorov-Smirnov test, contingency coefficient test, and ROC analysis were done to analyze the data obtained. Patients with metastatic lung cancer had higher SII than those without metastasis. The group of patients with metastasis had an average SII of 5391.34 and a PNI of 40.11. The group of patients without metastasis had an average SII of 2849.52 and PNI of 43.05. Lung cancer metastasis was correlated significantly with SII but not with PNI. The cut-off value was determined using the ROC curve. The cut-off value for SII was 2198.54 (68.5% sensitivity and 58.7% specificity) and for PNI was 42.2 (62% sensitivity and 54.3% specificity). SII was correlated with lung cancer metastasis and may be a promising indicator predicting of metastasis. PNI showed no significant correlation with lung cancer metastasis.
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| format | Article |
| id | doaj-art-8dd517fbfbce42e0a7d29c8ae0afe4d7 |
| institution | DOAJ |
| issn | 2684-6748 2656-9825 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Universitas Nahdlatul Ulama Surabaya |
| record_format | Article |
| series | Indonesian Journal of Medical Laboratory Science and Technology |
| spelling | doaj-art-8dd517fbfbce42e0a7d29c8ae0afe4d72025-08-20T03:18:02ZengUniversitas Nahdlatul Ulama SurabayaIndonesian Journal of Medical Laboratory Science and Technology2684-67482656-98252025-04-017110.33086/ijmlst.v7i1.5628The clinical value of systemic immune-inflammation index (SII) and prognostic nutritional index (PNI) for predicting the occurrence of metastasis in patients with lung cancerVerna Biutifasari0Ellen Angelique Hardjono1Ronald Pratama Adiwinoto2Janto Poernomo Hadi3Hang Tuah UniversityHang Tuah UniversityHang Tuah UniversityNaval Center Hospital Dr. Ramelan Surabaya Systemic immune-inflammation index (SII) and prognostic nutritional index (PNI) serve as simple and practical tests that help indicate inflammatory and nutritional status to some extent. Lung cancer stands out as the most common contributor to cancer-related mortality globally. It is associated with an unfavorable prognosis. Most patients diagnosed with lung cancer have metastasis at the time of diagnosis. Prognostic heterogeneity of cancer patients causes the need for more prognostic biomarkers. This study aimed to evaluate the clinical value of SII and PNI in predicting metastasis in lung cancer patients. SII and PNI provides a prognostic value in lung cancer. Retrospective cross-sectional research was conducted in this study involving 138 data from medical records at the Inpatient and Outpatient Department of Pulmonology, RSPAL dr. Ramelan Surabaya in April 2019 to July 2023. Kolmogorov-Smirnov test, contingency coefficient test, and ROC analysis were done to analyze the data obtained. Patients with metastatic lung cancer had higher SII than those without metastasis. The group of patients with metastasis had an average SII of 5391.34 and a PNI of 40.11. The group of patients without metastasis had an average SII of 2849.52 and PNI of 43.05. Lung cancer metastasis was correlated significantly with SII but not with PNI. The cut-off value was determined using the ROC curve. The cut-off value for SII was 2198.54 (68.5% sensitivity and 58.7% specificity) and for PNI was 42.2 (62% sensitivity and 54.3% specificity). SII was correlated with lung cancer metastasis and may be a promising indicator predicting of metastasis. PNI showed no significant correlation with lung cancer metastasis. http://journal2.unusa.ac.id/index.php/IJMLST/article/view/5628Systemic immune-inflammation indexPrognostic nutritional indexLung cancerPrognostic biomarker |
| spellingShingle | Verna Biutifasari Ellen Angelique Hardjono Ronald Pratama Adiwinoto Janto Poernomo Hadi The clinical value of systemic immune-inflammation index (SII) and prognostic nutritional index (PNI) for predicting the occurrence of metastasis in patients with lung cancer Indonesian Journal of Medical Laboratory Science and Technology Systemic immune-inflammation index Prognostic nutritional index Lung cancer Prognostic biomarker |
| title | The clinical value of systemic immune-inflammation index (SII) and prognostic nutritional index (PNI) for predicting the occurrence of metastasis in patients with lung cancer |
| title_full | The clinical value of systemic immune-inflammation index (SII) and prognostic nutritional index (PNI) for predicting the occurrence of metastasis in patients with lung cancer |
| title_fullStr | The clinical value of systemic immune-inflammation index (SII) and prognostic nutritional index (PNI) for predicting the occurrence of metastasis in patients with lung cancer |
| title_full_unstemmed | The clinical value of systemic immune-inflammation index (SII) and prognostic nutritional index (PNI) for predicting the occurrence of metastasis in patients with lung cancer |
| title_short | The clinical value of systemic immune-inflammation index (SII) and prognostic nutritional index (PNI) for predicting the occurrence of metastasis in patients with lung cancer |
| title_sort | clinical value of systemic immune inflammation index sii and prognostic nutritional index pni for predicting the occurrence of metastasis in patients with lung cancer |
| topic | Systemic immune-inflammation index Prognostic nutritional index Lung cancer Prognostic biomarker |
| url | http://journal2.unusa.ac.id/index.php/IJMLST/article/view/5628 |
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