Dual-mode-driven nanomotors targeting inflammatory macrophages for the MRI and synergistic treatment of atherosclerosis
Abstract With the progress of atherosclerosis (AS), the arterial lumen stenosis and compact plaque structure, the thickening intima and the narrow gaps between endothelial cells significantly limit the penetration efficiency of nanoprobe to plaque, weakening the imaging sensitivity and therapy effic...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-025-03136-0 |
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| author | Min Wei Qiaoji Jiang Shuang Bian Pengzhao Chang Bangbang Li Changzhou Shi Yangang Zhu Yanchen Wang Pingfu Hou Jingjing Li |
| author_facet | Min Wei Qiaoji Jiang Shuang Bian Pengzhao Chang Bangbang Li Changzhou Shi Yangang Zhu Yanchen Wang Pingfu Hou Jingjing Li |
| author_sort | Min Wei |
| collection | DOAJ |
| description | Abstract With the progress of atherosclerosis (AS), the arterial lumen stenosis and compact plaque structure, the thickening intima and the narrow gaps between endothelial cells significantly limit the penetration efficiency of nanoprobe to plaque, weakening the imaging sensitivity and therapy efficiency. Thus, in this study, a H2O2-NIR dual-mode nanomotor, Gd-doped mesoporous carbon nanoparticles/Pt with rapamycin (RAPA) loading and AntiCD36 modification (Gd-MCNs/Pt-RAPA-AC) was constructed. The asymmetric deposition of Pt on Gd-MCNs catalyzed H2O2 at the inflammatory site to produce O2, which could promote the self-motion of the nanomotor and ease inflammation microenvironment of AS plaque. Near-infrared (NIR) laser irradiation promoted the photothermal conversion of Gd-MCNs to generate the thermal propulsion of nanomotor and photothermal ablation of inflammatory macrophages. Meanwhile, the modification of AntiCD36 to bind with inflammatory macrophages further promotes the targeting effect. The released RAPA could inhibit the inflammatory side effects caused by photothermal effects, and promote macrophage autophagy to hinder the development of AS. The dual-mode propulsion nanomotors combining with the synergistic therapy of photothermal treatment, anti-inflammatory and pro-autophagy provided improved theranositc effect of AS. Graphical abstract |
| format | Article |
| id | doaj-art-8dc7d87a6f8b4823a45eecda9e934ef1 |
| institution | Kabale University |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-8dc7d87a6f8b4823a45eecda9e934ef12025-02-02T12:41:13ZengBMCJournal of Nanobiotechnology1477-31552025-01-0123112110.1186/s12951-025-03136-0Dual-mode-driven nanomotors targeting inflammatory macrophages for the MRI and synergistic treatment of atherosclerosisMin Wei0Qiaoji Jiang1Shuang Bian2Pengzhao Chang3Bangbang Li4Changzhou Shi5Yangang Zhu6Yanchen Wang7Pingfu Hou8Jingjing Li9School of Medical Imaging, Xuzhou Medical UniversityXuzhou Medical UniversitySchool of Medical Imaging, Xuzhou Medical UniversitySchool of Medical Imaging, Xuzhou Medical UniversitySchool of Medical Imaging, Xuzhou Medical UniversitySchool of Medical Imaging, Xuzhou Medical UniversitySchool of Medical Imaging, Xuzhou Medical UniversitySchool of Medical Imaging, Xuzhou Medical UniversityCancer Institute, Xuzhou Medical UniversitySchool of Medical Imaging, Xuzhou Medical UniversityAbstract With the progress of atherosclerosis (AS), the arterial lumen stenosis and compact plaque structure, the thickening intima and the narrow gaps between endothelial cells significantly limit the penetration efficiency of nanoprobe to plaque, weakening the imaging sensitivity and therapy efficiency. Thus, in this study, a H2O2-NIR dual-mode nanomotor, Gd-doped mesoporous carbon nanoparticles/Pt with rapamycin (RAPA) loading and AntiCD36 modification (Gd-MCNs/Pt-RAPA-AC) was constructed. The asymmetric deposition of Pt on Gd-MCNs catalyzed H2O2 at the inflammatory site to produce O2, which could promote the self-motion of the nanomotor and ease inflammation microenvironment of AS plaque. Near-infrared (NIR) laser irradiation promoted the photothermal conversion of Gd-MCNs to generate the thermal propulsion of nanomotor and photothermal ablation of inflammatory macrophages. Meanwhile, the modification of AntiCD36 to bind with inflammatory macrophages further promotes the targeting effect. The released RAPA could inhibit the inflammatory side effects caused by photothermal effects, and promote macrophage autophagy to hinder the development of AS. The dual-mode propulsion nanomotors combining with the synergistic therapy of photothermal treatment, anti-inflammatory and pro-autophagy provided improved theranositc effect of AS. Graphical abstracthttps://doi.org/10.1186/s12951-025-03136-0AtherosclerosisNanomotorsDual-mode drivenMR imagingPhotothermal therapy |
| spellingShingle | Min Wei Qiaoji Jiang Shuang Bian Pengzhao Chang Bangbang Li Changzhou Shi Yangang Zhu Yanchen Wang Pingfu Hou Jingjing Li Dual-mode-driven nanomotors targeting inflammatory macrophages for the MRI and synergistic treatment of atherosclerosis Journal of Nanobiotechnology Atherosclerosis Nanomotors Dual-mode driven MR imaging Photothermal therapy |
| title | Dual-mode-driven nanomotors targeting inflammatory macrophages for the MRI and synergistic treatment of atherosclerosis |
| title_full | Dual-mode-driven nanomotors targeting inflammatory macrophages for the MRI and synergistic treatment of atherosclerosis |
| title_fullStr | Dual-mode-driven nanomotors targeting inflammatory macrophages for the MRI and synergistic treatment of atherosclerosis |
| title_full_unstemmed | Dual-mode-driven nanomotors targeting inflammatory macrophages for the MRI and synergistic treatment of atherosclerosis |
| title_short | Dual-mode-driven nanomotors targeting inflammatory macrophages for the MRI and synergistic treatment of atherosclerosis |
| title_sort | dual mode driven nanomotors targeting inflammatory macrophages for the mri and synergistic treatment of atherosclerosis |
| topic | Atherosclerosis Nanomotors Dual-mode driven MR imaging Photothermal therapy |
| url | https://doi.org/10.1186/s12951-025-03136-0 |
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