Establishment of liquid biopsy procedure for the analysis of circulating cell free DNA, exosomes, RNA and proteins in colorectal cancer and adenoma patients

Establishment of liquid biopsy procedure for the analysis of circulating cell free DNA, exosomes, RNA and proteins in colorectal cancer and adenoma patients

Abstract Liquid biopsy has an underexplored diagnostic potential in colorectal cancer (CRC). Sufficient quantity and quality of its elements (circulating cell-free DNA (ccfDNA), exosomes and exosomal RNA) are essential for accurate results. The present study aims to establish the optimal protocol fo...

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Bibliographic Details
Main Authors: Andrea Čeri, Anita Somborac-Bačura, Marija Fabijanec, Andrea Hulina-Tomašković, Marko Matusina, Dijana Detel, Donatella Verbanac, Karmela Barišić
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Circulating tumour DNA
Colorectal cancer
Exosomes
Liquid biopsy
Methodology challenges
microRNA
Online Access:https://doi.org/10.1038/s41598-024-78497-x
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