Harnessing the Effect of Adoptively Transferred Tumor-Reactive T Cells on Endogenous (Host-Derived) Antitumor Immunity
Adoptive T cell transfer therapy, the ex vivo activation, expansion, and subsequent administration of tumor-reactive T cells, is already the most effective therapy against certain types of cancer. However, recent evidence in animal models and clinical trials suggests that host conditioning intervent...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2010/139304 |
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| author | Yolanda Nesbeth Jose R. Conejo-Garcia |
| author_facet | Yolanda Nesbeth Jose R. Conejo-Garcia |
| author_sort | Yolanda Nesbeth |
| collection | DOAJ |
| description | Adoptive T cell transfer therapy, the ex vivo activation, expansion, and subsequent administration of tumor-reactive T cells, is already the most effective therapy against certain types of cancer. However, recent evidence in animal models and clinical trials suggests that host conditioning interventions tailored for some of the most aggressive and frequent epithelial cancers will be needed to maximize the benefit of this approach. Similarly, the subsets, stage of differentiation, and ex vivo expansion procedure of tumor-reactive T cells to be adoptively transferred influence their in vivo effectiveness and may need to be adapted for different types of cancer and host conditioning interventions. The effects of adoptively transferred tumor-reactive T cells on the mechanisms of endogenous (host-derived) antitumor immunity, and how to maximize their combined effects, are further discussed. |
| format | Article |
| id | doaj-art-8dc4a76cd2fb42b7bdf0d80c95ec39f1 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-8dc4a76cd2fb42b7bdf0d80c95ec39f12025-02-03T05:48:16ZengWileyClinical and Developmental Immunology1740-25221740-25302010-01-01201010.1155/2010/139304139304Harnessing the Effect of Adoptively Transferred Tumor-Reactive T Cells on Endogenous (Host-Derived) Antitumor ImmunityYolanda Nesbeth0Jose R. Conejo-Garcia1Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USAThe Immunology Program, The Wistar Institute, Philadelphia, PA 19104, USAAdoptive T cell transfer therapy, the ex vivo activation, expansion, and subsequent administration of tumor-reactive T cells, is already the most effective therapy against certain types of cancer. However, recent evidence in animal models and clinical trials suggests that host conditioning interventions tailored for some of the most aggressive and frequent epithelial cancers will be needed to maximize the benefit of this approach. Similarly, the subsets, stage of differentiation, and ex vivo expansion procedure of tumor-reactive T cells to be adoptively transferred influence their in vivo effectiveness and may need to be adapted for different types of cancer and host conditioning interventions. The effects of adoptively transferred tumor-reactive T cells on the mechanisms of endogenous (host-derived) antitumor immunity, and how to maximize their combined effects, are further discussed.http://dx.doi.org/10.1155/2010/139304 |
| spellingShingle | Yolanda Nesbeth Jose R. Conejo-Garcia Harnessing the Effect of Adoptively Transferred Tumor-Reactive T Cells on Endogenous (Host-Derived) Antitumor Immunity Clinical and Developmental Immunology |
| title | Harnessing the Effect of Adoptively Transferred Tumor-Reactive T Cells on Endogenous (Host-Derived) Antitumor Immunity |
| title_full | Harnessing the Effect of Adoptively Transferred Tumor-Reactive T Cells on Endogenous (Host-Derived) Antitumor Immunity |
| title_fullStr | Harnessing the Effect of Adoptively Transferred Tumor-Reactive T Cells on Endogenous (Host-Derived) Antitumor Immunity |
| title_full_unstemmed | Harnessing the Effect of Adoptively Transferred Tumor-Reactive T Cells on Endogenous (Host-Derived) Antitumor Immunity |
| title_short | Harnessing the Effect of Adoptively Transferred Tumor-Reactive T Cells on Endogenous (Host-Derived) Antitumor Immunity |
| title_sort | harnessing the effect of adoptively transferred tumor reactive t cells on endogenous host derived antitumor immunity |
| url | http://dx.doi.org/10.1155/2010/139304 |
| work_keys_str_mv | AT yolandanesbeth harnessingtheeffectofadoptivelytransferredtumorreactivetcellsonendogenoushostderivedantitumorimmunity AT joserconejogarcia harnessingtheeffectofadoptivelytransferredtumorreactivetcellsonendogenoushostderivedantitumorimmunity |