Oncolytic immunotherapy: multiple mechanisms of oncolytic peptides to confer anticancer immunity
Oncolytic peptides are highly effective on remodeling the tumor microenvironment and potentiating the anticancer immunity through multiple mechanisms, particularly by inducing immunogenic cell death. Intriguingly, a recent study demonstrates that LTX-315, one of the most promising and extensively st...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2022-07-01
|
| Series: | Journal for ImmunoTherapy of Cancer |
| Online Access: | https://jitc.bmj.com/content/10/7/e005065.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832569404260352000 |
|---|---|
| author | Xing Huang Tingbo Liang Tianyu Tang Gang Zhang |
| author_facet | Xing Huang Tingbo Liang Tianyu Tang Gang Zhang |
| author_sort | Xing Huang |
| collection | DOAJ |
| description | Oncolytic peptides are highly effective on remodeling the tumor microenvironment and potentiating the anticancer immunity through multiple mechanisms, particularly by inducing immunogenic cell death. Intriguingly, a recent study demonstrates that LTX-315, one of the most promising and extensively studied oncolytic peptides, inhibits PD-L1 expression via ATP11B, thus enhancing the effectiveness of cancer immunotherapy by targeting the PD-1/PD-L1 axis. Therefore, this commentary discusses the broad effects and perspectives of oncolytic peptides on anticancer immunity, further highlighting the potential issues and directions of oncolytic peptides in cancer immunotherapy. |
| format | Article |
| id | doaj-art-8dc2c11b0a314f9b88879e4e4ebc334c |
| institution | Kabale University |
| issn | 2051-1426 |
| language | English |
| publishDate | 2022-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Journal for ImmunoTherapy of Cancer |
| spelling | doaj-art-8dc2c11b0a314f9b88879e4e4ebc334c2025-02-02T21:55:09ZengBMJ Publishing GroupJournal for ImmunoTherapy of Cancer2051-14262022-07-0110710.1136/jitc-2022-005065Oncolytic immunotherapy: multiple mechanisms of oncolytic peptides to confer anticancer immunityXing Huang0Tingbo Liang1Tianyu Tang2Gang Zhang3Zhejiang Clinical Research Center of Hepatobiliary and Pancreatic Diseases, Hangzhou, People`s Republic of ChinaThe Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, Hangzhou, People`s Republic of ChinaZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People`s Republic of ChinaZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People`s Republic of ChinaOncolytic peptides are highly effective on remodeling the tumor microenvironment and potentiating the anticancer immunity through multiple mechanisms, particularly by inducing immunogenic cell death. Intriguingly, a recent study demonstrates that LTX-315, one of the most promising and extensively studied oncolytic peptides, inhibits PD-L1 expression via ATP11B, thus enhancing the effectiveness of cancer immunotherapy by targeting the PD-1/PD-L1 axis. Therefore, this commentary discusses the broad effects and perspectives of oncolytic peptides on anticancer immunity, further highlighting the potential issues and directions of oncolytic peptides in cancer immunotherapy.https://jitc.bmj.com/content/10/7/e005065.full |
| spellingShingle | Xing Huang Tingbo Liang Tianyu Tang Gang Zhang Oncolytic immunotherapy: multiple mechanisms of oncolytic peptides to confer anticancer immunity Journal for ImmunoTherapy of Cancer |
| title | Oncolytic immunotherapy: multiple mechanisms of oncolytic peptides to confer anticancer immunity |
| title_full | Oncolytic immunotherapy: multiple mechanisms of oncolytic peptides to confer anticancer immunity |
| title_fullStr | Oncolytic immunotherapy: multiple mechanisms of oncolytic peptides to confer anticancer immunity |
| title_full_unstemmed | Oncolytic immunotherapy: multiple mechanisms of oncolytic peptides to confer anticancer immunity |
| title_short | Oncolytic immunotherapy: multiple mechanisms of oncolytic peptides to confer anticancer immunity |
| title_sort | oncolytic immunotherapy multiple mechanisms of oncolytic peptides to confer anticancer immunity |
| url | https://jitc.bmj.com/content/10/7/e005065.full |
| work_keys_str_mv | AT xinghuang oncolyticimmunotherapymultiplemechanismsofoncolyticpeptidestoconferanticancerimmunity AT tingboliang oncolyticimmunotherapymultiplemechanismsofoncolyticpeptidestoconferanticancerimmunity AT tianyutang oncolyticimmunotherapymultiplemechanismsofoncolyticpeptidestoconferanticancerimmunity AT gangzhang oncolyticimmunotherapymultiplemechanismsofoncolyticpeptidestoconferanticancerimmunity |