Fitness versus Fatness and Insulin Resistance in U.S. Adolescents
Background. The present study examined the relationship between insulin resistance and both waist circumference and cardiorespiratory fitness in U.S. adolescents. Methods. NHANES assessed a nationally representative sample of U.S. adolescents (12–18 yrs) between 1999–2002. Abdominal adiposity was e...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2010/195729 |
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| author | Doyle M. Cummings Katrina D. DuBose Satomi Imai David N. Collier |
| author_facet | Doyle M. Cummings Katrina D. DuBose Satomi Imai David N. Collier |
| author_sort | Doyle M. Cummings |
| collection | DOAJ |
| description | Background. The present study examined the relationship between insulin resistance and both
waist circumference and cardiorespiratory fitness in U.S. adolescents. Methods. NHANES assessed a nationally representative sample of U.S. adolescents (12–18 yrs) between 1999–2002. Abdominal adiposity was estimated by waist circumference, overall
adiposity by BMI, and cardiorespiratory fitness (maximal oxygen uptake (VO2max) from a
treadmill exercise test). Insulin resistance was estimated from fasting insulin and glucose using
the homeostatic model assessment method (i.e., HOMA) and was log-transformed.
Results. 1078 adolescents were included in the study. Positive correlations existed between
lnHOMA and waist circumference (r=0.59; r=0.54) for boys and girls, respectively. lnHOMA and VO2max were inversely related in boys (r=−0.29) but not girls (r=−0.06). Gender-specific analyses by BMI category showed that the significant inverse relationship in lnHOMA and VO2max was primarily present in obese boys.
Conclusion. Among adolescents, important gender and BMI differences exist in the relationship
between insulin resistance and fitness. While waist circumference and BMI are important
predictors in all children, fitness appears especially important in obese boys. These findings may
have important implications for gender-specific interventions to prevent adult obesity and
diabetes mellitus. |
| format | Article |
| id | doaj-art-8dbf4ba30beb42359c5db35e4fe14430 |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-8dbf4ba30beb42359c5db35e4fe144302025-02-03T06:06:03ZengWileyJournal of Obesity2090-07082090-07162010-01-01201010.1155/2010/195729195729Fitness versus Fatness and Insulin Resistance in U.S. AdolescentsDoyle M. Cummings0Katrina D. DuBose1Satomi Imai2David N. Collier3Brody School of Medicine, East Carolina University, 600 Moye Boulevard, Greenville, NC 27834, USACollege of Health and Human Performance, East Carolina University, Greenville, NC 27858, USACenter for Health Services Research and Development, East Carolina University, Greenville, NC 27858, USAPediatric Healthy Weight Research and Treatment Center, East Carolina University, Greenville, NC 27858, USABackground. The present study examined the relationship between insulin resistance and both waist circumference and cardiorespiratory fitness in U.S. adolescents. Methods. NHANES assessed a nationally representative sample of U.S. adolescents (12–18 yrs) between 1999–2002. Abdominal adiposity was estimated by waist circumference, overall adiposity by BMI, and cardiorespiratory fitness (maximal oxygen uptake (VO2max) from a treadmill exercise test). Insulin resistance was estimated from fasting insulin and glucose using the homeostatic model assessment method (i.e., HOMA) and was log-transformed. Results. 1078 adolescents were included in the study. Positive correlations existed between lnHOMA and waist circumference (r=0.59; r=0.54) for boys and girls, respectively. lnHOMA and VO2max were inversely related in boys (r=−0.29) but not girls (r=−0.06). Gender-specific analyses by BMI category showed that the significant inverse relationship in lnHOMA and VO2max was primarily present in obese boys. Conclusion. Among adolescents, important gender and BMI differences exist in the relationship between insulin resistance and fitness. While waist circumference and BMI are important predictors in all children, fitness appears especially important in obese boys. These findings may have important implications for gender-specific interventions to prevent adult obesity and diabetes mellitus.http://dx.doi.org/10.1155/2010/195729 |
| spellingShingle | Doyle M. Cummings Katrina D. DuBose Satomi Imai David N. Collier Fitness versus Fatness and Insulin Resistance in U.S. Adolescents Journal of Obesity |
| title | Fitness versus Fatness and Insulin Resistance in U.S. Adolescents |
| title_full | Fitness versus Fatness and Insulin Resistance in U.S. Adolescents |
| title_fullStr | Fitness versus Fatness and Insulin Resistance in U.S. Adolescents |
| title_full_unstemmed | Fitness versus Fatness and Insulin Resistance in U.S. Adolescents |
| title_short | Fitness versus Fatness and Insulin Resistance in U.S. Adolescents |
| title_sort | fitness versus fatness and insulin resistance in u s adolescents |
| url | http://dx.doi.org/10.1155/2010/195729 |
| work_keys_str_mv | AT doylemcummings fitnessversusfatnessandinsulinresistanceinusadolescents AT katrinaddubose fitnessversusfatnessandinsulinresistanceinusadolescents AT satomiimai fitnessversusfatnessandinsulinresistanceinusadolescents AT davidncollier fitnessversusfatnessandinsulinresistanceinusadolescents |